The Reds hold a 13-point lead over Arsenal at the summit, while the Saints are adrift of 17th place by the same amount, and here Sports Mole rounds up the team news for both clubs.
LIVERPOOL vs. SOUTHAMPTON
LIVERPOOL
Out: Tyler Morton (shoulder), Joe Gomez (hamstring), Conor Bradley (hamstring)
Doubtful: Cody Gakpo (knock)
Sports Mole's predicted XI: Alisson; Alexander-Arnold, Quansah, Van Dijk, Tsimikas; Gravenberch, Jones; Salah, Elliott, Diaz; Nunez
SOUTHAMPTON
Out: Adam Lallana (thigh), Ross Stewart (fitness), Juan Larios (fitness), Ryan Fraser (calf)
Doubtful: James Bree (hamstring), Kyle Walker-Peters (knock), Jan Bednarek (fatigue)
Sports Mole's predicted XI: Ramsdale; Sugawara, Harwood-Bellis, Bednarek, Bella-Kotchap, Manning; Fernandes, Ugochukwu, Smallbone, Sulemana; Onuachu
For data analysis of the most likely results, scorelines and more for this match please click here. Written by
Ben Knapton