Jurgen Klopp's men produced a trademark home turnaround to sink Brighton & Hove Albion 2-1 on Sunday, where Luis Diaz and Mohamed Salah cancelled out an early Danny Welbeck effort.
With Arsenal and Manchester City shaking hands on a goalless draw later in the day, the Reds hold a two-point lead over the Gunners at the summit of the rankings and are three better off than the reigning champions.
Here, Sports Mole rounds up Liverpool's latest injury and suspension news ahead of their showdown with the Blades, who let a 3-1 lead slip in a dramatic 3-3 draw with Fulham on Saturday.
Andrew Robertson
Status: Major doubt
Type of injury: Ankle
Possible return date: April 4 (vs. Sheffield United)
Andrew Robertson was unsurprisingly missing from the Liverpool squad for their battle with Brighton after sustaining an ankle injury while playing for Scotland, but his issue is not a severe one, and there is a chance that he could be involved in the midweek affair.
Diogo Jota
Status: Out
Type of injury: Knee
Possible return date: April 7 (vs. Manchester United)
Diogo Jota has spent a month and a half on the sidelines with the knee injury he picked up against Brentford in the middle of February, but he is on the verge of a return and might be considered for selection against Manchester United this weekend.
Curtis Jones
Status: Minor doubt
Type of injury: Shin
Possible return date: April 4 (vs. Sheffield United)
Curtis Jones was another casualty of that Bees victory with a shin issue, but he has now returned to the training pitches and is looking the likeliest to return for the Reds on Thursday evening.
Alisson Becker
Status: Out
Type of injury: Hamstring
Possible return date: April 18 (vs. Atalanta BC)
Last week, Klopp revealed to Liverpool fans on a tour of the club's training complex that Alisson Becker was between two-and-a-half and three weeks away from returning from a hamstring injury, which should theoretically mean that he is targeting a return for the second leg of their Europa League quarter-final with Atalanta BC.
Trent Alexander-Arnold
Status: Out
Type of injury: Knee
Possible return date: April 14 (vs. Crystal Palace)
Trent Alexander-Arnold was a special guest on Sky Sports during the Reds' win over Brighton as he continues to recuperate from a knee injury, which he revealed should clear up fully in a couple of weeks.
Thiago Alcantara
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Thiago Alcantara's solitary appearance this season came against Arsenal in February after his 10-month absence with a hip injury, but he sustained a severe muscular issue in that short Emirates cameo, and Klopp is not sure whether he will play again before the campaign is over.
Ben Doak
Status: Out
Type of injury: Knee
Possible return date: Unknown
Celtic product Ben Doak suffered a severe knee injury while playing for the youth team back in December, and as is the case with Thiago, it is also unclear whether the attacker can return in the closing stages of the season.
Joel Matip
Status: Out
Type of injury: Knee
Possible return date: Unknown
Experienced defender Joel Matip ruptured his anterior cruciate ligament just before Christmas, immediately ending his season and possibly his Liverpool career; the Cameroonian's contract will run out at the end of the season.
Stefan Bajcetic
Status: Out
Type of injury: Calf
Possible return date: Unknown
Long-term calf absentee Stefan Bajcetic is now taking part in partial training with the Reds' Under-21s and should be practising fully with the academy team this week, but he is still a few weeks away from first-team selection.
LIVERPOOL'S SUSPENSION LIST
Liverpool have no players suspended for this match.