The visit of the perennial Europa League winners marks Arne Slot's first game in the Anfield dugout, although only a few hours later, the Reds will take on Las Palmas behind closed doors.
However, with tens of thousands of fans entering through the turnstiles for the Sevilla showdown, Slot will likely bring out the big guns for that game, where several international stars could make their comebacks.
Indeed, all of Alexis Mac Allister, Alisson Becker, Joe Gomez, Trent Alexander-Arnold, Virgil van Dijk, Cody Gakpo, Luis Diaz and Darwin Nunez are primed and ready to get back to work, although Andrew Robertson (foot) is still injured.
As a result, Kostas Tsimikas should continue to hold the fort at left-back, although Van Dijk, Alisson and Alexander-Arnold could return to join Ibrahima Konate in a menacing-looking rearguard.
Curtis Jones (back) and Dominik Szoboszlai (fatigue) may not be risked from the off here, so the in-form Harvey Elliott could find himself alongside Wataru Endo and Ryan Gravenberch in the centre of the pitch.
Fabio Carvalho deserves a chance to strut his stuff in front of the Anfield faithful on account of his strong pre-season thus far, potentially as part of an attacking trident with Mohamed Salah and the returning Nunez.
Liverpool possible starting lineup:
Alisson; Alexander-Arnold, Konate, Van Dijk, Tsimikas; Elliott, Endo, Gravenberch; Salah, Nunez, Carvalho