The Ghana international served the fifth and final game of his prolonged suspension in Saturday's 5-2 loss to Arsenal, where the Irons were four goals down inside the opening 36 minutes.
Kudus may be lacking match practice, but he has no doubt been keeping himself sharp on the training pitches and should come straight back into the first XI in midweek, such is his importance to the visitors' offensive play.
Crysencio Summerville - who only lasted until half time at the weekend - is the most obvious candidate for the chop if Kudus is recalled immediately, as Carlos Soler justified his second straight start against Arsenal with a smart assist for Aaron Wan-Bissaka.
It remains to be seen whether Niclas Fullkrug's troublesome calf injury settles down in time for the contest with the Foxes, but Lopetegui should take no risks with the German as Michail Antonio, Lucas Paqueta and Jarrod Bowen complete the offensive line.
Edson Alvarez was only a half-time substitute against Arsenal following his own return from suspension but could now occupy the lone six role in place of Tomas Soucek, as Lopetegui rotates his resources amid the quick turnaround.
The Hammers' changes may not be limited to outfielders, though, as Lukasz Fabianski's brief stint in goal over Alphonse Areola may come to an end after Saturday's horror show against his old team.
However, unless Dinos Mavropanos can return from a virus in time for Tuesday, Wan-Bissaka, Emerson Palmieri, Max Kilman and Jean-Clair Todibo should form an unaltered defensive barrier.
West Ham United possible starting lineup:
Areola; Wan-Bissaka, Todibo, Kilman, Emerson; Alvarez; Bowen, Soler, Paqueta, Kudus; Antonio