Renato Tapia and Enric Franquesa both had to be substituted in the second half of the team's 1-0 win over Sevilla before the international break due to injury problems, and the pair have been ruled out of this contest.
Javi Hernandez for Franquesa should be a straight swap at left-back, while Tapia's absence is likely to open the door for Julian Chicco to feature in the middle of the midfield for a Leganes outfit that will be bidding to beat Real Madrid in La Liga for the first time in their history.
Miguel de la Fuente scored his first goal of the season from the penalty spot against Sevilla, and the 25-year-old is again expected to lead the line on Sunday, meaning that Sebastien Haller is likely to be among the substitutes.
Oscar Rodriguez and Roberto Lopez are two more players who will be in the thinking of their manager when it comes to potential changes, but the manner of the performance and result against Sevilla last time out suggests that it will be a similar side here.
Former Barcelona attacker Munir El Haddadi is set to continue down the left for the promoted outfit, while there will be a position at the back for ex-Manchester City centre-back Matija Nastasic.
Leganes possible starting lineup: Dmitrovic; Alti, Gonzalez, Nastasic, Hernandez; Chicco, Cisse; Cruz, Brasanac, El Haddadi; De la Fuente