The visitors, meanwhile, head to El Jadida aiming to record consecutive victories having returned to winning ways in their most recent outing.
Match preview
Guinea continued their recent resurgence with a hard-fought 2-1 triumph over the Fennec Foxes of Algeria at the Nelson Mandela Stadium on Thursday.
Kaba Diawara's men took the lead five minutes into the second half through Morlaye Sylla but were pegged back shortly afterwards by Yasser Balde's own goal after which Aguibou Camara decided the game just past the hour mark.
Consequently, the National Elephants have moved up to second place in their World Cup qualifying group, adrift of leaders Algeria only on goal difference.
Awaiting them next is the challenge of an opposing outfit who are yet to come out on top in any of the previous four editions of this fixture, suffering three defeats.
Having not lost a home game in just under a year, Monday's hosts will be confident of securing a positive result in front of their fans once again.
Mozambique snapped a four-game winless streak across all competitions by narrowly beating Somalia 2-1 at Estadio do Zimpeto on Friday afternoon.
Chiquinho Conde's men went into the interval with a commanding lead thanks to strikes from Alfons Amade and Stanley Ratifo before Ismail Shirwa pulled one back midway through the second half.
With six points picked up from three matches so far, Os Mambas sit fourth in the standings, level on points with the three sides above them in what is shaping up to be an enthralling battle in Group G.
Currently on a run of six straight away matches without a clean sheet, Monday's visitors have some tidying up to do at the back if they are to emerge triumphant on enemy territory.
Guinea World Cup Qualifying - Africa form:
W
L
W
Guinea form (all competitions):
L
W
L
W
W
W
Mozambique World Cup Qualifying - Africa form:
W
L
W
Mozambique form (all competitions):
W
D
D
L
D
W
Team News
Morlaye Sylla has found the back of the net five times in his last three appearances for Guinea, making him one to keep an eye on here.
Issiaga Sylla racked up his 81st international cap last time out and now sits just four shy of Pascal Feindouno's record of 85 for the hosts.
Forty-year-old Domingues Pelembe is showing no signs of slowing down in a Mozambique shirt off the back of his 112nd outing against Somalia.
Following his opener in the aforementioned game, Alfons Amade doubled his tally of international goals for the visitors and will be looking to pick up where he left off.
Guinea possible starting lineup:
Kone; Sylla, Diakite, Jeanvier, Sow, Balde; Camara, Diawara, Toure; Guirassy, Sylla
Mozambique possible starting lineup:
Ernani; Domingos, Mexer, Reinildo, Langa; Domingues, Guima, Amade; Catamo, Ratifo, Witi