The Lilywhites have already overcome Qarabag FK, Ferencvaros and AZ Alkmaar in the 2024-25 edition, eking out a 1-0 victory over the latter in October thanks to a Richarlison winner.
Ange Postecoglou's nine-point side are only trailing Lazio in second place in the 36-team table, and their fightback powers came to the fore in a 4-1 thrashing of Aston Villa in Sunday's Premier League affair.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of their showdown with Galatasaray, who lie fifth in the Europa League rankings on seven points.
Cristian Romero
Status: Major doubt
Type of injury: Foot
Possible return date: November 7 (vs. Galatasaray)
Cristian Romero was one of two casualties of the win over Villa, coming off with a foot problem just past the hour mark, and it would be a surprise to see the Argentine involved in Thursday's game.
Richarlison
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
In the process of setting up Dominic Solanke's second against the Lions, Richarlison pulled his hamstring and had to be substituted after coming off the bench himself; even if his problem is a minor one, he will certainly not be available for Thursday.
Micky van de Ven
Status: Out
Type of injury: Hamstring
Possible return date: November 23 (vs. Man City)
Spurs could be without both of their first-choice centre-backs this week, as Micky van de Ven also hurt his hamstring in the recent EFL Cup win over Manchester City and will not play again before the international break.
Djed Spence
Status: Major doubt
Type of injury: Groin
Possible return date: November 7 (vs. Galatasaray)
Djed Spence's groin problem prevented him from making the squad to face Villa, but the defender is thought to be in the final stages of his recovery and might be in contention to make his return on Thursday.
Wilson Odobert
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
After making a full recovery from one hamstring issue, Wilson Odobert was then immediately sidelined again with a "serious" setback, and the ex-Burnley winger will be out for some time.
TOTTENHAM'S SUSPENSION LIST
Tottenham have no players suspended for this match.
Valencia 
Getafe 
Werder Bremen 
RB Leipzig 
Fulham 
Everton 
Southampton 
Manchester City 
Celtic 
Hibernian 
Celta Vigo 
Sevilla 
Bordeaux 
Granville US 
Lazio 
Juventus 
Bayern Munich 
Borussia Monchengladbach 
CSKA Moscow 
Krasnodar 
Amiens 
Benfica 
Sporting CP 
Atletico Madrid 
Real Sociedad 
LE Havre 
Marseille 
Monaco 
Lyon 
Montpellier 
Paris Saint Germain 
Udinese 
Monza 
Newcastle 
Chelsea 
Rangers 
Aberdeen 
Leganes 
Espanyol 
Feyenoord 
PSV 
Manchester Utd 
West Ham 
Nottingham Forest 
Leicester 
Tottenham 
Crystal Palace 
Bayer Leverkusen 
Borussia Dortmund 
Fakel Voronezh 
Lokomotiv Moscow 
Barcelona 
Real Madrid 
Ajax 
NEC Nijmegen 
AZ Alkmaar 
Groningen 
Liverpool 
Arsenal