The Lilywhites have already overcome Qarabag FK, Ferencvaros and AZ Alkmaar in the 2024-25 edition, eking out a 1-0 victory over the latter in October thanks to a Richarlison winner.
Ange Postecoglou's nine-point side are only trailing Lazio in second place in the 36-team table, and their fightback powers came to the fore in a 4-1 thrashing of Aston Villa in Sunday's Premier League affair.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of their showdown with Galatasaray, who lie fifth in the Europa League rankings on seven points.
Cristian Romero
Status: Major doubt
Type of injury: Foot
Possible return date: November 7 (vs. Galatasaray)
Cristian Romero was one of two casualties of the win over Villa, coming off with a foot problem just past the hour mark, and it would be a surprise to see the Argentine involved in Thursday's game.
Richarlison
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
In the process of setting up Dominic Solanke's second against the Lions, Richarlison pulled his hamstring and had to be substituted after coming off the bench himself; even if his problem is a minor one, he will certainly not be available for Thursday.
Micky van de Ven
Status: Out
Type of injury: Hamstring
Possible return date: November 23 (vs. Man City)
Spurs could be without both of their first-choice centre-backs this week, as Micky van de Ven also hurt his hamstring in the recent EFL Cup win over Manchester City and will not play again before the international break.
Djed Spence
Status: Major doubt
Type of injury: Groin
Possible return date: November 7 (vs. Galatasaray)
Djed Spence's groin problem prevented him from making the squad to face Villa, but the defender is thought to be in the final stages of his recovery and might be in contention to make his return on Thursday.
Wilson Odobert
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
After making a full recovery from one hamstring issue, Wilson Odobert was then immediately sidelined again with a "serious" setback, and the ex-Burnley winger will be out for some time.
TOTTENHAM'S SUSPENSION LIST
Tottenham have no players suspended for this match.
Real Madrid 
Mallorca 
Everton 
Peterborough 
Dundee 
Rangers 
Nantes 
Monaco 
Concarneau 
Bordeaux 
Borussia Dortmund 
Bayer Leverkusen 
Lazio 
Como 
Liverpool 
Accrington ST 
Leicester 
QPR 
Udinese 
Atalanta 
1899 Hoffenheim 
VFL Wolfsburg 
FC ST. Pauli 
Eintracht Frankfurt 
Chelsea 
Morecambe 
Ross County 
Celtic 
Stade Brestois 29 
Lyon 
Torino 
Juventus 
Granville US 
Borussia Monchengladbach 
Bayern Munich 
Espanyol 
Leganes 
Manchester City 
Salford City 
Ajax 
Waalwijk 
Rodez 
AC Milan 
Cagliari 
Sporting CP 
Benfica 
Rennes 
Marseille 
PSV 
AZ Alkmaar 
Sevilla 
Valencia 
FC Porto 
Jacobina 
Tamworth 
Tottenham 
Feyenoord 
Utrecht