Sasa Kalajdzic, Boubacar Traore, Enso Gonzalez and Yerson Mosquera all remain sidelined as they continue to recover from long-term knee injuries, while teenager Bastien Meupiyou (muscle) is doubtful with a muscle problem.
Wolves made a request to the Uruguayan FA to recall Santiago Bueno earlier this month after the defender initially reported for international duty with a muscle injury; the 26-year-old will be assessed ahead of kickoff.
Hwang Hee-Chan will also be assessed after missing the last four matches with an ankle ligament injury. However, even if the South Korean was passed fit to feature against Fulham, he would not be expected to start in attack ahead of Matheus Cunha or Jorgen Strand Larsen.
Pablo Sarabia scored Wolves' fastest Premier League goal (01:48) in a 2-0 win over Southampton a fortnight ago, and he could continue in the final third with Cunha and Strand Larsen, although Carlos Forbs, Goncalo Guedes, Jean-Ricner Bellegarde and Rodrigo Gomes will provide strong competition for a starting spot.
Gary O'Neil will likely stick with Mario Lemina and Joao Gomes in centre-midfield, while Nelson Semedo, Craig Dawson, Toti Gomes, Bueno - if fit - and Rayan Ait-Nouri could all continue in defence. Jose Sa, meanwhile, may once again get the nod to start ahead of Sam Johnstone between the sticks.
Wolverhampton Wanderers possible starting lineup: Sa; Bueno, Dawson, Toti; Semedo, Lemina, Gomes, Ait-Nouri; Sarabia, Cunha; Strand Larsen