The two teams last locked horns in April when the Magpies secured a narrow 1-0 away victory thanks to a late strike from Bruno Guimaraes.
Match preview
Fulham have been left scratching their heads after a chastening three-day period in which they dropped two points from a winning position in the Premier League and suffered penalty-shootout heartache against lower-league opposition in the EFL Cup.
The Cottagers were seemingly on course to secure their second successive home league victory of the season last weekend, as they entered stoppage time one goal ahead against West Ham United, but Raul Jimenez's opener was cancelled out in the 95th minute by Hammers striker Danny Ings, forcing both sides to settle for a 1-1 draw.
Marco Silva's men then came out on the losing side of the longest penalty shootout in EFL Cup history, losing 16-15 to Championship outfit Preston North End on Tuesday night after playing out a 1-1 draw in 90 minutes at Deepdale.
Fulham's focus now shifts back to the Premier League where they currently sit 12th in the table; they have only won three of their last 13 top-flight fixtures, including results from last season, with two of those victories coming against newly-promoted teams.
Returning to winning ways is not a given for the Cottagers on Saturday, as they have failed to come out on top in any of their last eight Premier League meetings with Newcastle, losing each of their last five in a row.
Newcastle performances have been far from convincing so far this season, but Eddie Howe will have few complains as his side sit third in the Premier League with 10 points accumulated across their first four matches.
The Magpies beat Tottenham Hotspur 2-1 on home soil prior to the international break and followed that up a fortnight later with a victory by the same scoreline away against Wolverhampton Wanderers, courtesy of two stunning goals in the final 15 minutes from Fabian Schar and Harvey Barnes.
Three wins and one draw posted from four matches means that Newcastle, who sit just two points behind leaders Manchester City, have made their best start to a Premier League season since 1995-96 when they won each of their opening four games under Kevin Keegan.
Not since 2011-12 under Alan Pardew have Newcastle gone unbeaten in their first five Premier League fixtures, and Howe's current crop can be confident of success on Saturday as the Magpies have won each of their last five visits to Craven Cottage in all competitions.
Four of those have come in the Premier League by an impressive aggregate score of 11-1, including the aforementioned 1-0 away victory last season, having previously lost six in a row at Craven Cottage.
Fulham Premier League form:
Fulham form (all competitions):
L
W
W
D
D
L
Newcastle United Premier League form:
Newcastle United form (all competitions):
W
W
D
W
W
W
Team News
Fulham's only injury concern is with striker Carlos Vinicius, who is nursing a "small injury to his calf" and is not expected to return until the beginning of next month.
Silva made 11 changes for Fulham's penalty-shootout loss at Preston North End and the Portuguese boss is expected to revert to a similar side to the one that drew with West Ham last weekend, with Kenny Tete, Joachim Andersen, Calvin Bassey and Antonee Robinson all set to be recalled in defence.
Sander Berge is expected to link arms in midfield with Andreas Pereira, while Jimenez could once again lead the line at the expense of Rodrigo Muniz, with support to be provided in attack by Adama Traore, Emile Smith Rowe and Alex Iwobi.
As for Newcastle, Callum Wilson (back), Sven Botman, Jamaal Lascelles (both knee) and Lewis Miley (ankle) all remain sidelined with injuries.
The Magpies are sweating over the fitness of star striker Alexander Isak, who was forced off at half time against Wolves with an eye problem and has since picked up a toe injury, according to the Daily Mail.
Should Isak miss the trip to Fulham, either William Osula, Anthony Gordon or Joelinton could be tasked with leading the line; a start for Gordon as the central striker would open the door for Barnes to operate on the left flank.
Fulham possible starting lineup:
Leno; Tete, Andersen, Bassey, Robinson; Berge, Pereira; Traore, Smith Rowe, Iwobi; Jimenez
Newcastle United possible starting lineup:
Pope; Livramento, Schar, Burn, Hall; Tonali, Guimaraes, Joelinton; Murphy, Gordon, Barnes
We say: Fulham 1-1 Newcastle United
Newcastle have had plenty of success away against Fulham in recent years, but the potential absence of Isak would be a blow for the Magpies, who are already missing another central striker in Wilson.
None of Fulham's 16 Premier League home encounters with Newcastle have ended as a draw, but we can see this run coming to an end on Saturday and the spoils being shared in a closely-fought contest.