The 2007-born winger - who has already started against Ferencvaros and AZ Alkmaar in the Europa League this season - has been chosen by Ange Postecoglou to replace captain Son Heung-min, who misses out through injury once again.
Moore will start on the left flank ahead of Timo Werner, who must accept a place on the bench amid his current wasteful streak, while Wilson Odobert misses out entirely following his recent recovery from a hamstring injury.
Moore for Son is the only change that Postecoglou has made to his starting XI from the 4-1 win over West Ham United last weekend, while Palace head coach Oliver Glasner has made three alterations to the side that lost 1-0 to Nottingham Forest on Monday.
Ex-Arsenal striker Eddie Nketiah is one of the players to lose his place as Jean-Philippe Mateta is recalled to the attack, while Ismaila Sarr also replaces Daichi Kamada in the final third.
Finally, Adam Wharton makes an expected return to the hosts' XI over Will Hughes, having been an unused substitute in the defeat to Forest following a minor injury.
Tottenham starting lineup: Vicario; Porro, Romero, Van de Ven, Udogie; Kulusevski, Bissouma, Maddison; Johnson, Solanke, Moore
Subs: Forster, Davies, Dragusin, Gray, Bentancur, Sarr, Bergvall, Werner, Richarlison
Palace starting lineup: Henderson; Chalobah, Guehi, Lacroix; Munoz, Wharton, Lerma, Mitchell; Sarr, Eze; Mateta
Subs: Turner, Ward, Nketiah, Schlupp, Clyne, Kamada, Hughes, Kporha, Agbinone