The hosts are rock bottom of the table, only picking up six points from their 11 matches in the section, while Venezuela sit seventh - an Inter-confederation playoff spot - collecting 12 points from their opening 11 games.
Match preview
Chile have appeared in nine World Cups, famously finishing third at the 1962 tournament, but they have not qualified for the finals of the last two competitions, missing out in both 2018 and 2022.
The Reds have a tough task on their hands when it comes to finishing in the top seven of their current World Cup qualification group, as a disappointing campaign to date has left them at the bottom on six points from 11 matches.
Ricardo Gareca's side have only managed one win, while they have drawn three and lost seven of their 11 games, scoring just five times in the process, which has left them six points off seventh-placed Venezuela and 10 from Paraguay in sixth.
Chile will enter this match off the back of a goalless draw with Peru, which ended a four-game losing streak, while their only victory in the section came at home to Peru in October 2023.
The Reds have only ever lost four times to Venezuela in their history, but they have been beaten in two of the last three meetings between the two sides, including a 3-0 loss in the reverse game last October.
Venezuela will enter this match off the back of a 1-1 draw against Brazil, with Telasco Segovia cancelling out an opener from Raphinha to leave the two sides level, and that was ultimately how it finished.
Fernando Batista's side also held Argentina to a 1-1 draw last month, but they are winless in their last seven games in the section, with their last victory coming at home to Chile in October 2023.
La Vinotinto have a record of two wins, six draws and three defeats from 11 matches to collect 12 points, which has left them in seventh spot in the table, level on points with eighth-placed Bolivia.
Venezuela are currently in an an Inter-confederation playoff spot, and the fact that they have been difficult to beat will hand them confidence in their battle to book a spot at the 2026 World Cup.
The national team have incredibly never qualified for the finals of a World Cup, so it would be some achievement if Batista could guide the country to the tournament in 2026.
Chile World Cup Qualifying - South America form:
L
L
L
L
L
D
Chile form (all competitions):
D
L
L
L
L
D
Venezuela World Cup Qualifying - South America form:
D
L
D
D
L
D
Venezuela form (all competitions):
L
L
D
D
L
D
Team News
A lack of goals has been a major problem for Chile in this campaign, only finding the back of the net on five occasions, but Eduardo Vargas has 44 goals for his national side and will continue in the final third of the field here.
Alexander Aravena is yet to get off the mark for the national side, but he should be given another opportunity to score his first Chile goal during Tuesday's contest with Venezuela.
Captain Arturo Vidal is still going strong at the age of 37 and is in line for another start in midfield, while there is expected to be just a fourth cap for midfielder Vicente Pizarro.
As for Venezuela, Yangel Herrera will miss out with the injury that he suffered in the 15th minute of the clash with Brazil, which will open the door for Cristian Casseres to come into the XI.
The visitors will also be without the services of Alexander Gonzalez on Tuesday, with the 32-year-old picking up a straight red card just nine minutes after entering the field as a substitute against Brazil.
Salomon Rondon is Venezuela's all-time leading goalscorer with 45, and the 35-year-old is in line to win his 114th cap for his national side in this key 2026 World Cup qualification fixture.
Chile possible starting lineup:
Cortes; Loyola, Maripan, Diaz, Suazo; Vidal, Echeverria, Pizarro; Valdes; Aravena, Vargas
Venezuela possible starting lineup:
Romo; Aramburu, Ramirez, Angel, Navarro; Casseres, Martinez; Bello, Savarino, Murillo; Rondon
We say: Chile 0-0 Venezuela
Venezuela are the draw specialists in the section, sharing the points on six occasions, and while it would not be a surprise to see the visitors record a narrow win on Tuesday, we are expecting a tight and potentially uneventful match to finish goalless.