The home team have 37 points and are in sixth place following their 2-2 draw with Bournemouth on Tuesday, while Wolves are near the foot of the table in 17th place with 16 points, and were beaten 3-0 by Newcastle United on January 15.
Here, Sports Mole rounds up the team news for both clubs.
CHELSEA vs. WOLVERHAMPTON WANDERERS
CHELSEA
Out: Benoit Badiashile (muscle), Gabriel Slonina (finger), Wesley Fofana (hamstring)
Doubtful: Cole Palmer (knock), Enzo Fernandez (knock), Romeo Lavia (knock), Kiernan Dewsbury-Hall (knock), Levi Colwill (knock)
Sports Mole's predicted XI: Sanchez; James, Chalobah, Colwill, Cucurella; Fernandez, Caicedo; Madueke, Palmer, Sancho; Jackson
WOLVERHAMPTON WANDERERS
Out: Boubacar Traore (knee), Enso Gonzalez (cruciate ligament), Sasa Kalajdzic (cruciate ligament), Toti Gomes (hamstring), Yerson Mosquera (knee)
Doubtful: None
Sports Mole's predicted XI: Sa; Doherty, Bueno, Agbadou; R Gomes, Andre, J Gomes, Ait-Nouri; Hwang, Cunha; Larsen
For data analysis of the most likely results, scorelines and more for this match please click here. Written by
Lewis Nolan