Having recorded five successive victories during the league phase, the Blues have already booked their place in the last 16 of the competition.
Nevertheless, Enzo Maresca has decided to select a stronger team than anticipated, including just two players recognised as youngsters.
Fresh from signing a new long-term contract, Josh Acheampong features at right-back, while Tyrique George gets another run-out on the left flank.
Cesare Casadei is involved after missing last week's trip to Kazakhstan to face Astana through suspension, while Marc Guiu is rewarded for his two-goal haul in that game with another start.
Marc Cucurella is named at left-back courtesy of serving a suspension at the weekend, that enabling Renato Veiga to be deployed in the centre alongside Axel Disasi.
The likes of Noni Madueke and Christopher Nkunku also start, with Joao Felix expected to get a run-out from the substitutes' bench after a brief period with no game time.
How many Shamrock changes?
Meanwhile, Stephen Bradley has selected the same Shamrock Rovers XI from their 3-0 victory over Borna Banja Luka last week.
The Irish side will guarantee a place in the last 16 of this tournament if they can record a surprise victory at Stamford Bridge.
Chelsea XI: Jorgensen; Acheampong, Disasi, Veiga, Cucurella; Casadei, Dewsbury-Hall; Madueke, Nkunku, George; Guiu
Subs: Sanchez, Bergstrom, Tosin, Murray-Campbell, Dyer, Rak-Sakyi, Vale, Sancho, Neto, Felix, Mheuka
Shamrock Rovers XI: Pohls; Burns, Cleary, Farrugia, Grace, Honohan, Kenny, Lopes, O'Neill, Poom, Watts
Subs: Burke, Byrne, Clarke, Greene, Kavanagh, Mandriou, McEneff, A.Noonan, C.Noonan, Nugent, O'Sullivan, Steacy
Written by
Darren Plant