Head coach Enzo Maresca is currently negotiating a number of different competitions by selecting completely different starting lineups.
That worked again on Thursday night as the Blues recorded a 4-2 victory over Gent in their first league-phase fixture in the Europa Conference League.
Resting players is working wonders in reducing the amount of muscle injuries that Chelsea suffered last season, but one key player remains in the treatment room.
Here, Sports Mole rounds up Chelsea's injury and suspension news ahead of welcoming the East Midlands outfit to the capital.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Having missed the start of the season with a hamstring injury, James recently posted a message of 'see you soon' on social media. However, even if the right-back was in a position to return this weekend, Maresca and the club's medical staff would err on the side of caution and wait until after the international break.
CHELSEA'S SUSPENSION LIST
Chelsea have no players who are suspended for this fixture.
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen