With five fresh injury concerns emerging ahead of this contest, alterations were always likely to be made after the 4-2 victory over Leicester City in the FA Cup quarter-finals.
However, the Argentine has arguably not tinkered with his team as expected, with Mykhaylo Mudryk switching to the left despite making an impact against the Foxes from a central position.
Raheem Sterling has dropped down to the substitutes' bench, while each of goalkeeper Robert Sanchez and defender Trevoh Chalobah miss out through injury.
Goalkeeper Djordje Petrovic is back between the sticks, while Benoit Badiashile makes his first start since February in the middle of the backline.
Although he only returned from international duty on Thursday after playing for Argentina in a friendly in the United States, Enzo Fernandez plays in central midfield.
Ben Chilwell misses out with the dead leg sustained while representing England, but Cole Palmer has been passed fit to start on the right wing.
Meanwhile, Vincent Kompany has made two changes to the Burnley team that started the 2-1 victory over Brentford in their last Premier League outing.
One change is enforced courtesy of David Datro Fofana being ineligible to face his parent club, that resulting in Lyle Foster being restored in the final third.
Meanwhile, Zeki Amdouni is also recalled in place of Charlie Taylor, the likelihood being that Vitinho will feature at full-back.
Chelsea: Petrovic; Gusto, Disasi, Badiashile, Cucurella; Caicedo, Fernandez, Gallagher; Palmer, Jackson, Mudryk
Subs: Bettinelli, Gilchrist, Silva, Acheampong, Casadei, Tauriainen, Madueke, Sterling, Washington
Burnley: Muric; Assignon, O'Shea, Esteve, Vitinho; Berge, Cullen; Amdouni, Odobert, Bruun Larsen; Foster
Subs: Trafford, Taylor, Cork, Gudmundsson, Brownhill, Rodriguez, Benson, Ekdal, Tresor