With the 3-0 victory over West Ham United coming just three days ago, the head coach has opted to ring the changes for the meeting with the League Two outfit.
Malo Gusto has shaken off a thigh injury to take his place at right-back, with Axel Disasi partnering Benoit Badiashile in the middle and Renato Veiga on the left.
Kiernan Dewsbury-Hall comes into the engine room alongside Cesare Casadei, the latter being one of the players reintegrated back into the first-team ranks having failed to secure a transfer elsewhere.
As expected, there is an entirely fresh look in the final third with Christopher Nkunku leading the line ahead of Pedro Neto, Joao Felix and Mykhaylo Mudryk.
There are the notable inclusions of Ben Chilwell and Carney Chukwuemeka on the substitutes' bench, the pair each hoping to earn their first minutes of the season.
Academy graduates Josh Acheampong and Tyrique George, as well as young Brazilian Deivid Washington and former Barcelona prospect Marc Guiu, also takes their spots among the replacements.
Chelsea XI: Jorgensen; Gusto, Disasi, Badiashile, Veiga; Casadei, Dewsbury-Hall; Neto, Felix, Mudryk; Nkunku
Subs: Bettinelli, Acheampong, Chilwell, Colwill, Fernandez, Chukwuemeka, George, Washington, Guiu
How do Barrow line up?
Barrow had made the trip to West London sitting at the top of the League Two standings, conceding just three goals and collecting 16 points from a possible 21.