On Friday, it was revealed that Axel Disasi and Enzo Fernandez had been added to the club's injury list, while Raheem Sterling was also absent from training at the time due to illness.
None of those three players have made the squad for the encounter with the Merseyside outfit, with Malo Gusto and Mykhaylo Mudryk being brought back into the team.
Unlike against Sheffield United when he was used on the flank, Conor Gallagher will revert to a central position alongside Moises Caicedo.
Ben Chilwell is able to return to the squad after a minor knee injury and illness, while Trevoh Chalobah and Thiago Silva get the nod over Benoit Badiashile.
Meanwhile, Sean Dyche has also made two alterations to his Everton starting lineup, one enforced with Dominic Calvert-Lewin missing out on a place in the squad entirely.
Beto is the natural replacement for the England international, while Amadou Onana is able to come back into the team to replace Andre Gomes.
Everton's options off the substitutes' bench are also boosted by the return of Arnaut Danjuma.
Chelsea: Petrovic; Gusto, Chalobah, Silva, Cucurella; Caicedo, Gallagher, Palmer; Madueke, Jackson, Mudryk
Subs: Bettinelli, Chilwell, Gilchrist, Badiashile, Casadei, Dyer, Chukwuemeka, George, Washington
Everton: Pickford; Coleman, Tarkowski, Branthwaite, Mykolenko; Onana, Garner, Doucoure; McNeil, Beto, Young
Subs: Virginia, Patterson, Keane, Danjuma, Harrison, Gomes, Godfrey, Chermiti, Warrington