Winks was forced off after just 11 minutes in the Foxes' 2-1 defeat to Chelsea last weekend with a groin injury and he has emerged as a major doubt for the trip to the capital.
Abdul Fatawu (ACL), Ricardo Pereira (thigh) and Jakub Stolarczyk (ankle) all remain sidelined with injuries, but Facundo Buonanotte is available to return after serving a one-match ban last time out.
Following the sacking of head coach Steve Cooper and expected appointment of Ruud van Nistelrooy, it remains to be seen how Leicester will line up for Saturday's contest and whether many changes will be made.
Jannik Vestergaard will be hoping to force his way back into the first XI after being dropped from the matchday squad by Cooper last weekend. The Dane is set to compete with Caleb Okoli for a start in central defence alongside Wout Faes.
In the potential absence of Winks, Oliver Skipp could be recalled to start in centre-midfield alongside Boubakary Soumare, with Wilfred Ndidi operating in a slightly more advanced role just in front.
Kasey McAteer was handed his first Premier League start against Chelsea and will hope to fend off competition from Buonanotte, Bobby De-Cordova Reid and Jordan Ayew for another start on the right flank as Bilal El Khannouss and Stephy Mavididi battle for a place on the left, while Jamie Vardy leads the line.
Leicester City possible starting lineup: Hermansen; Justin, Faes, Vestergaard, Kristiansen; Skipp, Ndidi, Soumare; Buonanotte, Vardy, Mavididi