The result has moved the Bees into sixth spot in the Premier League table, now boasting 23 points from their opening 15 matches of the campaign, while Newcastle remain 12th, having collected 20 points from their first 15 games.
Sean Longstaff hit one off the post in the early stages of the contest, but Brentford made the breakthrough in the eighth minute, with Bryan Mbeumo working his way into the Newcastle box before finding the top corner with a brilliant effort.
Newcastle were only behind for three minutes, though, with Alexander Isak heading a cross from Jacob Murphy into the back of the net from close range to spark jubilant scenes in the away end at the Brentford Community Stadium.
Brentford regained the lead in the 28th minute through Yoane Wissa, who found the back of the net with a brilliant effort, but it was 2-2 just four minutes later, as Harvey Barnes fired into the bottom corner after being found by Murphy.
Barnes had given the ball away to Wissa for Brentford's second, but it was a quick-fire response from the Newcastle forward, and a pulsating opening 45 minutes in West London finished all square at 2-2.
Brentford were back ahead in the 56th minute, as a long free kick from their goalkeeper Mark Flekken reached Collins, with the defender expertly finishing into the bottom corner of the net.
Schade then made sure of the points in the final stages by converting from inside the box after smart work from man-of-the-match Mbeumo, with Brentford winning the six-goal thriller to climb into sixth, now just four points off the Champions League positions.
BRENTFORD VS. NEWCASTLE HIGHLIGHTS
8th min: Brentford 1-0 Newcastle (Bryan Mbeumo)
Mbeumo makes the breakthrough in the eighth minute of the match, as the 25-year-old brilliantly works his way into the away side's penalty box before picking out the top corner; Newcastle fall behind in the early exchanges here.
11th min: Brentford 1-1 Newcastle (Alexander Isak)
Newcastle strike back three minutes after falling behind, with Isak heading a cross from Murphy into the back of the net; it has been some start to this match, with the score already 1-1 after just 11 minutes of action.
28th min: Brentford 2-1 Newcastle (Yoane Wissa)
Brentford regain the lead in the 28th minute of the match, as Wissa picks out the back of the net with a brilliant effort after a misplaced pass from Barnes; it was a brilliant effort from the striker.
32nd min: Brentford 2-2 Newcastle (Harvey Barnes)
It is absolutely raining goals here; Barnes makes up for his error by scoring the fourth goal of this match, with the attacker sliding one into the bottom corner off another pass from Murphy.
56th min: Brentford 3-2 Newcastle (Nathan Collins)
The fifth goal in this match comes for Brentford, with Collins on the scoresheet, as the defender converts from inside the box following a long free kick from Flekken; not sure about the defending from Newcastle there!
92nd min: Brentford 4-2 Newcastle (Kevin Schade)
Brentford secure all the points in the final stages of the contest, as the substitute produces an excellent finish after being released by Mbeumo, who has been the star of the show this afternoon.
MAN OF THE MATCH - BRYAN MBEUMO
Mbeumo operated as a right-sided wing-back against Newcastle on Saturday afternoon, and it was a terrific performance from the 25-year-old, who made the breakthrough in the early stages with an excellent finish before turning provider for Schade in the latter stages.
The Cameroon international had two successful dribbles, while he completed 31 of his 39 passes against the Magpies, with Mbeumo contributing heavily for Brentford at both ends of the field.
BRENTFORD VS. NEWCASTLE MATCH STATS
Possession: Brentford 45%-55% Newcastle
Shots: Brentford 11-16 Newcastle
Shots on target: Brentford 8-3 Newcastle
Corners: Brentford 3-4 Newcastle
Fouls: Brentford 10-7 Newcastle
WHAT NEXT?
Brentford will be bidding to make it successive wins in the Premier League when they head to Chelsea next Sunday, before facing Newcastle once again in the quarter-finals of the EFL Cup on December 18.
Newcastle, meanwhile, will be aiming to bounce back from the disappointing result when they host Leicester City in the league next Sunday, before the contest in the last eight of the League Cup.
Written by
Matt Law