Botafogo duo Igor Jesus and Luiz Henrique came to Brazil's rescue, as they came from 1-0 down to win 2-1 in Santiago on Thursday, handing the Selecao a crucial three points in their pursuit to reach the finals in North America.
On debut, Igor Jesus started and scored the equaliser for Brazil, before Luiz Henrique was introduced in the second half and fired home an 89th-minute winner.
Endrick was dropped after Brazil's underwhelming performances in September, and even though Savinho started last week, the influence of Luiz Henrique could see him rewarded with a place in the side.
The win did come with a downside though, as Dorival will be without Lucas Paqueta for this one, with his yellow card triggering a one-match suspension, and he has been replaced in the squad by former West Bromwich Albion man Matheus Pereira.
That will likely see Bruno Guimaraes come into the team to partner Andre in the midfield, after the Newcastle United man only started as a substitute in Santiago.
It is still a toss-up over who will start at left-back, as Abner was handed his international debut against Chile, but Alex Telles has been in fine form for an impressive Botafogo side of late.
On the injury front, Alisson will miss out with the hamstring injury that is set to keep him sidelined for the next month or so, while Vinicius Junior also withdrew with a neck injury, breaking up the potential for a Real Madrid trio starting in attack.
Bremer's season-ending knee injury means he is not available, and fellow centre-back Eder Militao is also not in the squad, so Marquinhos and Gabriel Magalhaes are set to feature again at the back.
Brazil possible starting lineup:
Ederson; Danilo, Marquinhos, Gabriel, Abner; Bruno Guimaraes, Andre; Raphinha, Luiz Henrique, Igor Jesus; Rodrygo