Ange Postecoglou's side head into this fixture having collected four points from their last two Premier League fixtures, albeit there being disappointment over only earning a share of the spoils versus Fulham on Sunday.
The North London outfit begin the latest matchday in seventh position in the Premier League table, five points adrift of second-placed Arsenal.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of their showdown with Bournemouth, who are on a high having hit four past Wolverhampton Wanderers last time out.
Guglielmo Vicario
Status: Out
Type of injury: Ankle
Possible return date: Unknown
First-choice goalkeeper Vicario remarkably played for over an hour at the Etihad Stadium last month with a broken ankle, which he has since undergone surgery for, and Postecoglou has confirmed that the Italian faces months out of action.
Cristian Romero
Status: Minor doubt
Type of injury: Toe
Possible return date: December 5 (vs. Fulham)
Romero is ever closer to coming back from a toe injury. Having missed out against Fulham, the Argentina international could be back in the squad for this contest.
Richarlison
Status: Out
Type of injury: Hamstring
Possible return date: January 15 (vs. Arsenal)
Richarlison's hamstring problem is expected to render him unavailable until the early stages of January, potentially meaning that he could make his comeback in the next North London derby.
Micky van de Ven
Status: Out
Type of injury: Hamstring
Possible return date: December 19 (vs. Manchester United)
Unlike Richarlison, Micky van de Ven's hamstring problem may have completely healed before the end of 2024, but the Dutchman will not be back in action for approximately three more weeks.
Wilson Odobert
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Just after making a comeback from one hamstring problem, summer signing Odobert sustained an even more severe injury in the same area and will be out for the long-term after undergoing an operation.
Mikey Moore
Status: Out
Type of injury: Illness
Possible return date: December 12 (vs. Rangers)
Teenage sensation Moore has been laid low by a troublesome illness this month, and Postecoglou has conceded that it will be the middle of the month before the 17-year-old makes his return.
Dominic Solanke
Status: Minor doubt
Type of injury: Illness
Possible return date: December 5 (vs. Bournemouth)
Solanke had been due to feature against Fulham on Sunday, only for Postecoglou to send him home when it became apparent that he was suffering with an illness. However, the forward is likely to be contention to face his old club.
Archie Gray
Status: Major doubt
Type of injury: Knock
Possible return date: December 5 (vs. Bournemouth)
Gray needed to be withdrawn shortly after his introduction on Sunday after sustaining what Postecoglou described as a dead leg. If the youngster is passed fit to feature on the South coast, he will be selected among the replacements.
TOTTENHAM'S SUSPENSION LIST
Rodrigo Bentancur
Return date: December 12 (vs. Rangers)
Bentancur serves the third of his seven-match domestic suspension for an offensive comment that he made about Son Heung-min and South Koreans over the summer, but he will return for Spurs' next Europa League game.