Manuel Pellegrini's side will enter the contest off the back of a 2-1 success over Getafe, while Mallorca recorded an impressive 1-0 victory over Real Sociedad in their last match.
Match preview
Real Betis only picked up two points from their opening three league matches of the season, drawing with Girona and Alaves before suffering a 2-0 loss to Real Madrid immediately before the international break.
Pellegrini's side have managed to win their last two, though, recording a 2-0 victory over Leganes on September 13 before beating Getafe 2-1 five days later.
Giovani Lo Celso scored a brace against Getafe, with the result moving the Seville outfit onto eight points, which is enough for eighth position in the table, three points behind fourth-placed Villarreal.
The Green and Whites will play in the Conference League this season, meanwhile, opening their campaign against Legia Warsaw at the start of October, but they will first take on Mallorca, Las Palmas and Espanyol in Spain's top flight.
Real Betis have won each of their last five league games against Mallorca, including a 1-0 success when the two teams last locked horns in January, and they are unbeaten against Monday's opponents since May 2013.
Mallorca are actually on a run of eight La Liga matches without a win over Real Betis, and they have not even scored in their last three contests with the Green and Whites in Spain's top flight.
Jagoba Arrasate's side started their 2024-25 La Liga campaign with a 1-1 draw against Real Madrid, but they were then beaten by Osasuna and held by Sevilla in their next two matches.
Mallorca's first league win of the season came away to Leganes at the end of August, but they were unable to build on that result, losing 2-1 at home to Villarreal on September 14.
The Pirates will enter this match off the back of an impressive result, though, beating Real Sociedad 1-0 on Tuesday night, with Abdon Prats' first-half penalty deciding the match.
Mallorca have picked up eight points from their opening six league games of the season to sit in ninth position, boasting a record of two wins, two draws and two defeats in Spain's top flight this term.
Real Betis La Liga form:
Real Betis form (all competitions):
W
D
W
L
W
W
Mallorca La Liga form:
D
L
D
W
L
W
Team News
Real Betis will be without the services of William Carvalho and Isco through injury, while Marc Bartra remains a doubt for the home team due to a muscular complaint.
Pellegrini's team did not pick up any fresh problems against Getafe, and there is a chance that they could welcome Johnny Cardoso back into their squad on Monday.
Vitor Roque, who is on loan at the club from Barcelona, is set to continue in the XI, while there will be another start for Lo Celso, who hit a brace last time out.
As for Mallorca, Pablo Maffeo will definitely miss out due to a muscular injury, while Siebe Van der Heyden and Javi Llabres are major doubts.
Toni Lato will be back from a suspension, but there is a chance that head coach Arrasate will name an unchanged side from the one that took to the field against Real Sociedad.
The only alteration could come in the final third of the field, with Muriqi, who netted against Real Madrid in game week one, set to be recalled, which would see Cyle Larin drop down to the bench.
Real Betis possible starting lineup:
Silva; Bellerin, Natan, Llorente, Perraud; Roca, Lo Celso, Altimira; Fornals, Roque, Ezzalzouli
Mallorca possible starting lineup:
Roman; Sanchez, Raillo, Copete, Mojica; Costa, Mascarell; Navarro, Prats, Darder; Muriqi
We say: Real Betis 1-1 Mallorca
Real Betis will be the favourites on home soil, but Mallorca have only conceded four times in six league matches this season, and we believe that the Pirates have enough quality to secure what would be a welcome point.