Hansi Flick's side are currently four points clear of second-placed Real Madrid at the summit, while Real Betis occupy 10th spot in the division, and here Sports Mole rounds up the team news ahead of their clash in Seville.
REAL BETIS vs. BARCELONA
REAL BETIS
Out: Johnny Cardoso (hip), Nobel Mendy (knee), Hector Bellerin (muscle), Marc Roca (knee), William Carvalho (knee), Isco (ankle)
Doubtful: Pablo Fornals (muscle)
Sports Mole's predicted XI: Silva; Sabaly, Bartra, Llorente, Perraud; Guirao, Altimira; Fornals, Lo Celso, Ezzalzouli; Roque
BARCELONA
Out: Marc Bernal (knee), Andreas Christensen (Achilles), Marc-Andre ter Stegen (knee), Ronald Araujo (hamstring), Ansu Fati (hamstring)
Doubtful: None
Sports Mole's predicted XI: Pena; Kounde, Cubarsi, I Martinez, Balde; Pedri, Casado; Yamal, Olmo, Raphinha; Lewandowski
For data analysis of the most likely results, scorelines and more for this match please click here. Written by
Matt Law