The Catalan outfit will enter the match off the back of a 5-1 victory over Mallorca on Tuesday night, with the result leaving them top of the La Liga table, four points clear of second-placed Real Madrid, who have two games in hand.
Hansi Flick's side have only won one of their last four league matches, though, suffering two defeats in the process, so they will be aiming to make it back-to-back successes in Spain's top flight for the first time since the start of November.
Here, Sports Mole rounds up Barcelona's injury and suspension news ahead of the clash with Real Betis, who suffered a 2-0 defeat to Real Sociedad in La Liga last time out.
Ronald Araujo
Status: Out
Type of injury: Hamstring
Possible return date: December 15 (vs. Leganes)
Araujo will again miss out for Barcelona here, but the centre-back has revealed that he is making excellent progress in his recovery from a hamstring operation, with his return set to come before the winter break.
Andreas Christensen
Status: Out
Type of injury: Achilles
Possible return date: Unknown
Christensen remains on the treatment table with an Achilles problem, and it has been reported that the Denmark international has had a setback in his recovery, with the defender set to be missing for at least another couple of months.
Marc Bernal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Bernal suffered an ACL injury against Rayo Vallecano in the league earlier this term, and he is out for the season, with the youngster working to be ready for pre-season ahead of the 2025-26 campaign.
Marc-Andre ter Stegen
Status: Out
Type of injury: Knee
Possible return date: Unknown
Barcelona will be missing their number one goalkeeper Ter Stegen for the remainder of the season due to the serious knee injury that he suffered in the clash with Villarreal on September 22.
Ansu Fati
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Barcelona revealed last week that Fati had picked up a thigh problem during a training session, and the attacker now faces a battle to be available before the winter break in Spain.
BARCELONA'S SUSPENSION LIST
Barcelona have no players suspended for the La Liga clash.
Written by
Matt Law