Olmo, having finally been registered with La Liga, was able to make his debut for the club off the bench against Rayo Vallecano on Tuesday night, and he came up with the game's winning goal.
The summer arrival from RB Leipzig is now in line for his first start for Barcelona, with Ferran Torres likely to be the player to make way in terms of the starting XI.
Marc Bernal, 17, suffered a devastating ACL injury in the latter stages of the clash with Rayo Vallecano, with the midfielder now set to be missing for the remainder of the campaign.
Bernal has joined Andreas Christensen, Eric Garcia, Ronald Araujo, Gavi, Ansu Fati and Frenkie de Jong on the sidelines, with Barcelona currently missing seven first-team players.
Olmo for Torres is likely to be one change for this weekend's match, while Fermin Lopez and Alejandro Balde could come in for Bernal and Gerard Martin.
Due to the midfield absences, it is likely that Pedri and Fermin will be asked to play slightly deeper, with Olmo then joining Lamine Yamal, Raphinha and Robert Lewandowski in the forward positions.
Barcelona possible starting lineup: Ter Stegen; Kounde, Cubarsi, I Martinez, Balde; Fermin, Pedri; Yamal, Olmo, Raphinha; Lewandowski