Xavi's side are second in the table, four points ahead of third-placed Girona, while Rayo occupy 15th and still have a slight chance of being relegated this season.
Here, Sports Mole rounds up the team news for the two sides ahead of the clash.
BARCELONA vs. RAYO VALLECANO
BARCELONA
Out: Gavi (knee), Alejandro Balde (hamstring), Frenkie de Jong (ankle)
Doubtful: Ronald Araujo (knee)
Sports Mole's predicted XI: Ter Stegen; Kounde, Cubarsi, I Martinez, Cancelo; Fermin, Christensen, Gundogan; Yamal, Lewandowski, Raphinha
RAYO VALLECANO
Out: Oscar Trejo (suspended), Diego Mendez (ligament)
Doubtful: None
Sports Mole's predicted XI: Dimitrievski; Balliu, Mumin, Lejeune, Espino; U Lopez, Valentin; Palazon, A Garcia, De Frutos; Camello
For data analysis of the most likely results, scorelines and more for this match please click here.