The Catalan outfit were held to a 2-2 draw by Real Betis in Spain's top flight last weekend, but Hansi Flick's side remain top of the La Liga table, two points ahead of second-placed Real Madrid, who have a game in hand.
The division leaders secured a huge three points in the Champions League on Wednesday night, meanwhile, as they recorded a 3-2 victory over Borussia Dortmund in Germany.
Here, Sports Mole rounds up Barcelona's injury and suspension news ahead of the clash with Leganes, who sit in 17th spot in Spain's top flight, boasting 15 points from their opening 16 games of the campaign.
Ronald Araujo
Status: Minor doubt
Type of injury: Hamstring
Possible return date: December 15 (vs. Leganes)
Araujo was back on the bench against Dortmund, with the defender recovering from a hamstring operation, and the Uruguay international is now set to make his first appearance of the campaign in the clash with Leganes.
Andreas Christensen
Status: Major doubt
Type of injury: Achilles
Possible return date: December 15 (vs. Leganes)
Christensen has been missing since the first gameweek of the campaign with an Achilles problem, but the Denmark international is now back in training and could return to the field before the winter break.
Marc Bernal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Bernal suffered an ACL injury against Rayo Vallecano in the league earlier this term, and he is out for the season, with the youngster working to be ready for pre-season ahead of the 2025-26 campaign.
Marc-Andre ter Stegen
Status: Out
Type of injury: Knee
Possible return date: Unknown
Barcelona will be missing their number one goalkeeper Ter Stegen for the remainder of the season due to the serious knee injury that he suffered in the clash with Villarreal on September 22.
Ansu Fati
Status: Major doubt
Type of injury: Thigh
Possible return date: December 15 (vs. Leganes)
Fati has been sidelined since last month with a thigh problem, but the Spaniard is now back in first-team training and in line to return before the winter break, potentially this weekend.
BARCELONA'S SUSPENSION LIST
Barcelona have no players suspended for the La Liga clash.
Written by
Matt Law
Zorya Luhansk 
Shakhtar Donetsk 
Polissya Zhytomyr 
Dynamo Kyiv 
Bordeaux 
VFL Wolfsburg 
1899 Hoffenheim 
Sampdoria 
Salernitana 
AC Milan 
Bologna 
Valencia 
Getafe 
Werder Bremen 
RB Leipzig 
Fulham 
Everton 
Southampton 
Manchester City 
Celtic 
Hibernian 
Celta Vigo 
Sevilla 
Granville US 
Lazio 
Juventus 
Bayern Munich 
Borussia Monchengladbach 
CSKA Moscow 
Krasnodar 
Amiens 
Benfica 
Sporting CP 
Atletico Madrid 
Real Sociedad 
LE Havre 
Marseille 
Monaco 
Lyon 
Montpellier 
Paris Saint Germain 
Udinese 
Monza 
Newcastle 
Chelsea 
Rangers 
Aberdeen 
Leganes 
Espanyol 
Feyenoord 
PSV 
Manchester Utd 
West Ham 
Nottingham Forest 
Leicester 
Tottenham 
Crystal Palace