Hansi Flick's men currently sit four points clear of rivals Real Madrid in second having played a game more than Los Blancos, who take on Getafe on Sunday.
After failing to win their last two La Liga matches, Barca returned to winning ways in the Champions League on Tuesday night when they secured a 3-0 victory over Brest.
Here, Sports Mole rounds up Barcelona's latest injury and suspension news ahead of the contest with Las Palmas.
Marc-Andre ter Stegen
Status: Out
Type of injury: Knee
Possible return date: Unknown
First-choice goalkeeper Ter Stegen is ruled out for the remainder of the season due to the serious knee injury he suffered in a clash with Villarreal on September 22.
Marc Bernal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Bernal suffered an ACL injury against Rayo Vallecano in the league earlier this season and he is out for the rest of the campaign, with the youngster working to be ready for pre-season ahead of 2025-26.
Andreas Christensen
Status: Out
Type of injury: Achilles
Possible return date: Unknown
Christensen remains on the treatment table with an Achilles problem, and it has been reported that the Denmark international has had a setback in his recovery, with the defender set to be missing for at least another couple of months.
Ansu Fati
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Barcelona revealed earlier this month that Fati had picked up a thigh problem during a training session and the attacker now faces a battle to be available before the winter break in Spain.
Ronald Araujo
Status: Out
Type of injury: Hamstring
Possible return date: December 3 (vs. Mallorca)
Saturday's game will likely come too soon for Araujo, but the centre-back recently revealed that he is making excellent progress in his recovery from a hamstring operation, with his return set to come in early December.
Ferran Torres
Status: Minor doubt
Type of injury: Thigh
Possible return date: November 30 (vs. Las Palmas)
Barcelona have been without the services of versatile forward Torres due to the thigh problem he suffered during his side's clash with Alaves before October's international break, but there is a slight chance that the Spaniard could be back for Saturday's game.
Lamine Yamal
Status: Minor doubt
Type of injury: Ankle
Possible return date: November 30 (vs. Las Palmas)
Yamal has missed Barcelona's last three matches with an ankle injury, but Flick is optimistic that the 17-year-old sensation will be available for selection and could be "an option from the bench" against Las Palmas.
BARCELONA'S SUSPENSION LIST
Marc Casado will serve a one-match suspension following his red card for two bookable offences against Celta Vigo last weekend.