Hansi Flick's side will enter the Catalan derby off the back of an incredible 4-0 victory over Real Madrid in El Clasico, with the result moving them six points clear at the top of the La Liga table.
Barcelona have scored 21 times in their last five matches in all competitions, while they have already managed 37 goals in Spain's top flight during an impressive campaign to date.
Here, Sports Mole rounds up Barcelona's injury and suspension news ahead of the clash with Espanyol, who sit 17th in the division, picking up 10 points from their opening 11 matches of the season.
Ronald Araujo
Status: Out
Type of injury: Hamstring
Possible return date: November 26 (vs. Brest)
Araujo will again miss out for Barcelona against Espanyol, but the centre-back has revealed that he is making excellent progress in his recovery from a hamstring operation, with his return set to come before the end of November.
Andreas Christensen
Status: Out
Type of injury: Achilles
Possible return date: November 10 (vs. Real Sociedad)
Christensen remains on the treatment table with an Achilles problem, but the Denmark international is said to be in the latter stages of his recovery, with a return to action potentially occurring before the November international break.
Marc Bernal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Bernal suffered an ACL injury against Rayo Vallecano in the league earlier this term, and he is out for the season, with the youngster working to be ready for pre-season ahead of the 2025-26 campaign.
Marc-Andre ter Stegen
Status: Out
Type of injury: Knee
Possible return date: Unknown
Barcelona will be missing their number one goalkeeper Ter Stegen for the remainder of the season due to the serious knee injury that he suffered in the clash with Villarreal on September 22.
Ferran Torres
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Barcelona remain without the services of versatile forward Torres due to the thigh problem that he suffered during his side's clash with Alaves before the October international break.
Eric Garcia
Status: Major doubt
Type of injury: Muscle
Possible return date: November 3 (vs. Espanyol)
Barcelona have been without Garcia for their last three matches due to a muscular problem, and it remains to be seen whether the defender recovers in time for the Catalan derby.
BARCELONA'S SUSPENSION LIST
Barcelona have no players suspended for the La Liga clash.