Hansi Flick's side are sixth in the Champions League table on nine points, while Brest are fourth, having picked up 10 points thus far, and here Sports Mole rounds up the team news ahead of their European contest.
BARCELONA vs. BREST
BARCELONA
Out: Ansu Fati (hamstring), Marc Bernal (knee), Andreas Christensen (Achilles), Marc-Andre ter Stegen (knee), Ronald Araujo (hamstring)
Doubtful: Lamine Yamal (ankle), Ferran Torres (hamstring), Eric Garcia (hernia)
Sports Mole's predicted XI: Pena; Kounde, Cubarsi, I Martinez, Balde; De Jong, Casado; Olmo, Pedri, Raphinha; Lewandowski
BREST
Out: Bradley Locko (Achilles)
Doubtful: Pierre Lees-Melou (leg), Massadio Haidara (muscle), Romain Faivre (ankle) and Soumaila Coulibaly (pelvis), Abdallah Sima (muscle)
Sports Mole's predicted XI: Bizot; Lala, Chardonnet, Le Cardinal, Amavi; Camara, Lees-Melou, Fernandes; Balde, Ajorque, Doumbia
For data analysis of the most likely results, scorelines and more for this match please click here.