Real Madrid are second in the La Liga table, boasting 17 points from their opening seven matches, while Atletico sit third, picking up 15 points from their first seven games of 2024-25.
Both are unbeaten in the league this season, and it is shaping up to be another fascinating battle between two of the giants of world football.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides ahead of their contest in Spain's top flight.
Head-to-head record
Previous meetings: 236
Atletico wins: 59
Draws: 61
Real Madrid wins: 116
These two sides have locked horns on 236 occasions throughout history, and it is Real Madrid that lead the head-to-head record, having won 116 matches to Atletico's 59, while there have also been 61 draws.
In La Liga, the two rivals have faced off 174 times, with Real Madrid also unsurprisingly leading the head-to-head, boasting 91 league wins to Atletico's 41, with 42 draws also occurring.
There have also been nine Champions League encounters, with Real Madrid winning five of those, including the finals of the 2013-14 and 2015-16 competitions.
The last La Liga meeting took place at Bernabeu in February, with the two teams playing out a 1-1 draw, but Atletico beat Real Madrid 4-2 in the Copa del Rey at the start of this year.
Real Madrid's last league defeat actually came against Atletico in the early stages of last season, with Los Blancos now incredibly unbeaten in over a year in Spain's top flight.
Atletico are unbeaten in their last three league games against Real Madrid, with two of those finishing in draws, while they have only lost one of their last five against their rivals in Spain's top flight.
Real Madrid do have a recent away victory to their name over Atletico, though, recording a 2-1 win in the early stages of the 2022-23 La Liga campaign.
Cristiano Ronaldo is unsurprisingly the all-time leading goalscorer in the Madrid derby, with the Real Madrid legend scoring 22 times against Atletico during his time in Spanish football.
Throughout history, this fixture has been dominated by Real Madrid, but Atletico have had plenty of recent success over their rivals, and Sunday's contest at Wanda Metropolitano is shaping up to be an intriguing affair.
Last 20 meetings
Feb 04, 2024: Real Madrid 1-1 Atletico (La Liga)
Jan 18, 2024: Atletico 4-2 Real Madrid (Copa del Rey Round of 16)
Jan 10, 2024: Real Madrid 5-3 Atletico (Supercopa de Espana Semi-Finals)
Sep 24, 2023: Atletico 3-1 Real Madrid (La Liga)
Feb 25, 2023: Real Madrid 1-1 Atletico (La Liga)
Jan 26, 2023: Real Madrid 3-1 Atletico (Copa del Rey Quarter-Finals)
Sep 18, 2022: Atletico 1-2 Real Madrid (La Liga)
May 08, 2022: Atletico 1-0 Real Madrid (La Liga)
Dec 12, 2021: Real Madrid 2-0 Atletico (La Liga)
Mar 07, 2021: Atletico 1-1 Real Madrid (La Liga)
Dec 12, 2020: Real Madrid 2-0 Atletico (La Liga)
Feb 01, 2020: Real Madrid 1-0 Atletico (La Liga)
Jan 12, 2020: Real Madrid 0-0 Atletico (Supercopa de Espana Final)
Sep 28, 2019: Atletico 0-0 Real Madrid (La Liga)
Jul 27, 2019: Real Madrid 3-7 Atletico (friendly Pre-season Friendlies)
Feb 09, 2019: Atletico 1-3 Real Madrid (La Liga)
Sep 29, 2018: Real Madrid 0-0 Atletico (La Liga)
Aug 15, 2018: Real Madrid 2-4 Atletico (UEFA Super Cup UEFA Super Cup)
Apr 08, 2018: Real Madrid 1-1 Atletico (La Liga)
Nov 18, 2017: Atletico 0-0 Real Madrid (La Liga)
Last 10 La Liga meetings
Feb 04, 2024: Real Madrid 1-1 Atletico (La Liga)
Sep 24, 2023: Atletico 3-1 Real Madrid (La Liga)
Feb 25, 2023: Real Madrid 1-1 Atletico (La Liga)
Sep 18, 2022: Atletico 1-2 Real Madrid (La Liga)
May 08, 2022: Atletico 1-0 Real Madrid (La Liga)
Dec 12, 2021: Real Madrid 2-0 Atletico (La Liga)
Mar 07, 2021: Atletico 1-1 Real Madrid (La Liga)
Dec 12, 2020: Real Madrid 2-0 Atletico (La Liga)
Feb 01, 2020: Real Madrid 1-0 Atletico (La Liga)
Sep 28, 2019: Atletico 0-0 Real Madrid (La Liga)
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