The Lions eked out a 2-1 win over West Ham United in round three, while Spurs overcame non-league Tamworth 3-0 after extra time, and here Sports Mole rounds up the team news for both clubs.
ASTON VILLA vs. TOTTENHAM HOTSPUR
ASTON VILLA
Out: Axel Disasi (cup-tied), Ollie Watkins (groin), Pau Torres (ankle), Matty Cash (unspecified), Tyrone Mings (knee), Ross Barkley (calf)
Doubtful: None
Sports Mole's predicted XI: Olsen; Garcia, Kamara, Konsa, Maatsen; Tielemans, Onana; Rogers, McGinn, Ramsey; Malen
TOTTENHAM HOTSPUR
Out: Richarlison (calf), Guglielmo Vicario (ankle), Radu Dragusin (knee), Wilson Odobert (hamstring), Dominic Solanke (knee), James Maddison (calf), Micky van de Ven (fitness), Destiny Udogie (hamstring), Cristian Romero (thigh), Timo Werner (thigh), Brennan Johnson (calf)
Doubtful: None
Sports Mole's predicted XI: Kinsky; Porro, Danso, Davies, Spence; Bissouma, Bentancur, Bergvall; Kulusevski, Tel, Son
For data analysis of the most likely results, scorelines and more for this match please click here. Written by
Ben Knapton