While the Gunners made extremely light work of Bolton Wanderers in a 5-1 midweek mauling, the Foxes only just scraped past Walsall on penalties thanks to a trio of 12-yard stops from goalkeeper Danny Ward.
The two sides have also experienced vastly contrasting Premier League fortunes to date, as Mikel Arteta's men remain unbeaten in fourth place, while the 15th-ranked visitors are still searching for their maiden top-flight win of the season.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
Head-to-head record
Previous meetings: 150
Arsenal wins: 72
Draws: 45
Leicester wins: 33
From exactly 150 previous meetings between Arsenal and Leicester City, the Gunners unsurprisingly trump their less esteemed counterparts in the wins column with 72 victories, while the Foxes have only prevailed on 33 occasions.
The Gunners' most recent triumph in this head-to-head came at the King Power Stadium in February 2023, where Gabriel Martinelli notched the only goal of the game and also injured himself in the process, sealing Arsenal's fifth straight win in this fixture.
Arteta's men had also conquered the Foxes 4-2 at home in the earliest stages of the 2022-23 campaign, and should they manage to see off Cooper's team on Saturday afternoon, they would have beaten Leicester six times on the bounce for the first time in their history.
However, Arsenal's most recent defeat to the 2015-16 Premier League champions came at the Emirates Stadium in October 2020, when none other than Jamie Vardy bagged the only goal of the contest, one of 11 he had scored versus the Gunners to date.
The 37-year-old Leicester talisman has scored more against Arsenal than any other team in his career - also bagging 11 against Watford down the years - and he also struck at the Emirates during an unforgettable affair in the 2015-16 season.
Vardy's penalty would not prove telling that day, as Theo Walcott levelled the contest 20 minutes from time before Danny Welbeck met a Mesut Ozil free kick with a delightfully deft header, sending the Emirates into pandemonium before Claudio Ranieri's men still went on to claim a sensational title.
Vardy's 11 efforts in this fixture makes him the highest documented scorer in matches between Arsenal and Leicester, but Thierry Henry and Dennis Bergkamp enjoyed facing the Foxes too, netting six and five goals against them respectively.
In terms of current Arsenal attackers, Gabriel Jesus has made a habit of haunting Leicester with seven goals and two assists against them for both Manchester City and Arsenal - his nine direct involvements is more than he has managed against any other Premier League side.
Last 20 meetings
Feb 25, 2023: Leicester 0-1 Arsenal (Premier League)
Aug 13, 2022: Arsenal 4-2 Leicester (Premier League)
Mar 13, 2022: Arsenal 2-0 Leicester (Premier League)
Oct 30, 2021: Leicester 0-2 Arsenal (Premier League)
Feb 28, 2021: Leicester 1-3 Arsenal (Premier League)
Oct 25, 2020: Arsenal 0-1 Leicester (Premier League)
Sep 23, 2020: Leicester 0-2 Arsenal (EFL Cup Third Round)
Jul 07, 2020: Arsenal 1-1 Leicester (Premier League)
Nov 09, 2019: Leicester 2-0 Arsenal (Premier League)
Apr 28, 2019: Leicester 3-0 Arsenal (Premier League)
Oct 22, 2018: Arsenal 3-1 Leicester (Premier League)
May 09, 2018: Leicester 3-1 Arsenal (Premier League)
Aug 11, 2017: Arsenal 4-3 Leicester (Premier League)
Apr 26, 2017: Arsenal 1-0 Leicester (Premier League)
Aug 20, 2016: Leicester 0-0 Arsenal (Premier League)
Feb 14, 2016: Arsenal 2-1 Leicester (Premier League)
Sep 26, 2015: Leicester 2-5 Arsenal (Premier League)
Feb 10, 2015: Arsenal 2-1 Leicester (Premier League)
Aug 31, 2014: Leicester 1-1 Arsenal (Premier League)
May 15, 2004: Arsenal 2-1 Leicester (Premier League)
Last 10 Premier League meetings
Feb 25, 2023: Leicester 0-1 Arsenal (Premier League)
Aug 13, 2022: Arsenal 4-2 Leicester (Premier League)
Mar 13, 2022: Arsenal 2-0 Leicester (Premier League)
Oct 30, 2021: Leicester 0-2 Arsenal (Premier League)
Feb 28, 2021: Leicester 1-3 Arsenal (Premier League)
Oct 25, 2020: Arsenal 0-1 Leicester (Premier League)
Jul 07, 2020: Arsenal 1-1 Leicester (Premier League)
Nov 09, 2019: Leicester 2-0 Arsenal (Premier League)
Apr 28, 2019: Leicester 3-0 Arsenal (Premier League)
Oct 22, 2018: Arsenal 3-1 Leicester (Premier League)
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