The Gunners are bidding to win the competition for the first time since 1993, while their visitors have already beaten Mansfield Town and Shrewsbury Town in this year's edition, and here Sports Mole rounds up the team news for both clubs.
ARSENAL vs. BOLTON WANDERERS
ARSENAL
Out: Leandro Trossard (suspended), Neto (cup-tied), Mikel Merino (shoulder), Martin Odegaard (ankle), Takehiro Tomiyasu (knee), Oleksandr Zinchenko (calf), Kieran Tierney (hamstring)
Doubtful: David Raya (leg), Riccardo Calafiori (knock), Jurrien Timber (cramp)
Sports Mole's predicted XI: Raya; White, Heaven, Kiwior, Lewis-Skelly; S Oulad M'Hand, Jorginho; Saka, Nwaneri, Sterling; Jesus
BOLTON WANDERERS
Out: Jordi Osei-Tutu (knee), Carlos Mendes Gomes (Achilles), Klaidi Lolos (ankle), Gethin Jones (knee), Will Forrester (toe)
Doubtful: None
Sports Mole's predicted XI: Southwood; Toal, Johnston, Santos; Dacres-Cogley, Thomason, Arfield, Dempsey, Schon; Adeboyejo, Charles
For data analysis of the most likely results, scorelines and more for this match please click here.