The Gunners need just a point away at Girona to join Premier League rivals Liverpool in guaranteeing their place in the last 16.
Mikel Arteta's men sit third in the new-look table after five wins from their opening seven European matches and still could finish second.
Even if Arsenal fall to a shock defeat to La Liga side Girona, results elsewhere will likely confirm their spot in the top eight regardless.
Liverpool and Barcelona are the only two sides to have already booked their knockout spot, with Aston Villa hoping to follow.
However, Manchester City will have to make do with a play-off place at best - which could prove a potential financial headache.
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Champions League prize money
All 36 clubs in the League Phase have banked €18.62m (£15.6m) for participating, with €2.1m (£1.7m) per win and €700,000 (£587k) per draw.
Each position in the table is worth €275,000 (£230k) - which means the team that finishes second last in 35th claim double that at €550,000 (£461k) through to €9.9m (£8.3m) for the table-toppers.
The top eight will also rake in a €2m (£1.6m) bonus, with clubs finishing ninth to 16th earning €1m (£830k).
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The prize money for reaching each knockout round only increases as well, with the outright winners at the Allianz Arena claiming £21.1m.
Performance-related prize money accounts for 37.5 per cent (€914m, £766m) of the overall pot, with UEFA's newly created value pillar taking up 35 per cent to split up broadcast revenue, and the final 27.5 per cent being equalled shared between the 36 clubs.
Champions League: How to follow
All 18 games of matchday eight in the Champions League will be played on Wednesday, January 29.
Kick-off around Europe is simultaneously scheduled for 8pm.
talkSPORT will have live coverage from Aston Villa against Celtic, with Adrian Durham serving as your presenter from the Etihad Stadium.
Commentary will come from Jim Proudfoot and former England captain Andy Townsend.
talkSPORT 2 will also be on hand for City's do-or-die clash with Club Brugge, with Ian Danter and Stuart Pearce on the microphone.
talkSPORT.com will also have updates from ALL 18 matches in our dedicated live Champions League blog.
To tune in to talkSPORT through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Champions League knockout teams
Confirmed into Round of 16
Liverpool, Barcelona
Confirmed in Round of 16 or knockout phase play-offs
Arsenal, Aston Villa, Atalanta, Atletico Madrid, Bayern Munich, Brest, Celtic, Dortmund, Feyenoord, Inter Milan, Juventus, Leverkusen, Lille, AC Milan, Monaco, Real Madrid
Competing for knockout phase play-off places
Manchester City, PSG, Club Brugge, Benfica, PSV, Sporting Lisbon, Stuttgart, Dinamo Zagreb, Shakhtar Donetsk
Eliminated
Bologna, Red Star Belgrade, Girona, Leipzig, Slovan Bratislava, Sparta Prague, Sturm Graz, Young Boys
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Champions League fixtures
Here, are the full fixtures for matchday eight...
Aston Villa (9th) v Celtic (18th)
Barcelona (2nd) v Atalanta (7th)
Bayer Leverkusen (8th) v Sparta Prague (29th)
Bayern Munich (15th) v Slovan Bratislava (35th)
Borussia Dortmund (14th) v Shakhtar Donetsk (27th)
Brest (13th) v Real Madrid (16th)
Dinamo Zagreb (26th) v AC Milan (6th)
Girona (31st) v Arsenal (3rd)
Inter Milan (4th) v Monaco (10th)
Juventus (17th) v Benfica (21st)
Lille (12th) v Feyenoord (11th)
Man City (25th) v Brugge (20th)
PSV (19th) v Liverpool (1st)
RB Salzburg (34th) v Atletico Madrid (5th)
Sporting Lisbon (23rd) v Bologna (28th)
Sturm Graz (33rd) v RB Leipzig (30th)
Stuttgart (24th) v PSG (22nd)
Young Boys (36th) v Red Star Belgrade (32nd)