La Roja played out a goalless draw with Portugal on Friday, and there will be a temptation for Enrique to make wholesale alterations for this match ahead of their Euro 2020 opener against Sweden on June 14.
The head coach will want to continue to build relationships in the side ahead of the European Championships, though, and it is therefore expected to be a strong Spain side for this match.
Jordi Alba could replace Jose Gaya at left-back, but Aymeric Laporte should win his second cap in the middle of the defence, with Pau Torres also set to start for the home side.
The midfield three could remain unchanged, with Sergio Busquets being joined by Fabian Ruiz and Thiago Alcantara, although Koke, Pedri and Rodri are all options for change.
Gerard Moreno scored 30 goals and registered 11 assists in 46 appearances for Villarreal last season, and the 29-year-old could come in for a start, potentially replacing Pablo Sarabia.
Alvaro Morata could again get the nod through the middle, though, with Ferran Torres potentially edging out Dani Olmo and Mikel Oyarzabal to feature in a wide area.
Spain possible starting lineup: Simon; M Llorente, Laporte, P Torres, Alba; Thiago, Busquets, Ruiz; F Torres, Morata, G Moreno