Top-six chasing Brighton face fierce rivals Crystal Palace while relegation-threatened Southampton host Brentford.
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But don't worry as talkSPORT have you covered once again with EXCLUSIVE live commentary of both top-flight games on the south coast this week.
talkSPORT 2 will have coverage of Brighton vs Crystal Palace with commentary coming from Alex Crook and former England defender Alvin Martin.
While you can listen to coverage of Southampton vs Brentford on the talkSPORT app with commentary coming from Ian Danter and former Saints striker David Connolly.
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Why are the games not on TV?
Both of these games are not on TV as their original fixtures were not selected for broadcast.
If the original fixture is not chosen for broadcast then even if they are rescheduled, they will still not be shown on TV.
Brighton vs Crystal Palace was meant to take place very early in the season in September but it was postponed due to a rail strike.
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This was then rescheduled to be played on Thursday, March 16 before once again the date was changed.
Another rail strike was announced and in turn, the Premier League moved the kick-off to 24 hours earlier on Wednesday so that fans would have access to transport.
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As for Southampton vs Brentford, their original fixture was postponed due to the death of Queen Elizabeth II.
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After a long wait for a new date, the clubs finally found out that the game would take place on Wednesday, March 15 last month.
Both matches will kick off at 7:30pm so make sure to tune in to all of talkSPORT's coverage this week!
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.