The Reds and Citizens are two of the main teams that can say they are in the title race, so all eyes will be on Anfield when they meet.
Of course, it will be Jurgen Klopp's last game as a Premier League manager against Pep Guardiola, with the German leaving Liverpool at the end of the season.
So, it's all set up to be a cracker between two of the best top-flight sides of recent years.
When is Liverpool vs Man City?
Liverpool will welcome Man City to Anfield on Sunday, March 10.
This is four days after the second leg of City's Champions League last-16 clash against Copenhagen and will be three days after the first leg of Liverpool's Europa League last-16 game.
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The Reds are yet to find out their opponent for this match and could be at home or away.
The game will kick-off at 3:45pm because Merseyside police wanted an earlier start to ensure fan safety after numerous incidents between the two sets of supporters over the last few years.
Before this game in March, Liverpool have four Premier League matches and City have five, including their postponed clash from earlier in the season against Brentford.
But Liverpool boast a strong home record against City, winning eight of the last 11 meetings at Anfield, including a 1-0 victory last year.
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The Citizens have only recorded one victory at Anfield since Guardiola became manager.
However, City now have Kevin De Bruyne back and Erling Haaland, so they are starting to hit top gear.
Meanwhile, Liverpool will hope to have Mohamed Salah back from a hamstring injury.
With both sides well in the Premier League title race, this match could decide who lifts the trophy in May.