The Blues battled to a 2-1 win over Watford on Wednesday in a game Thomas Tuchel admitted his side were 'lucky' to leave with three points.
Chelsea were far from their usual selves, perhaps down to a host of key players missing, but remain a point clear of second-placed Manchester City.
West Ham meanwhile have faltered in recent weeks after an impressive start to the season, losing two and drawing one in their last three games.
West Ham v Chelsea: live commentary
This Premier League clash will take place on Saturday, December 4 at the London Stadium with a UK kick-off time of 12:30pm.
Coverage will start from 11am with Reshmin Chowdhury on presenting duties.
Commentary will then come from Joe Shennan and former England striker Dean Ashton.
To tune in to talkSPORT or talkSPORT 2, click HERE for the live stream.
App iPhone - Download from the Apple store
Android - Download from Google Play
Radio - talkSPORT is available across the United Kingdom via DAB digital radio and on 1089 or 1053 AM
TV - Listen to talkSPORT through your TV on the following channels: Sky: Channel 0108 Virgin Media: Channel 927 Freeview: Channel 723 Freesat: Channel 731
West Ham v Chelsea: Team news
The hosts will hope to welcome back Aaron Cresswell after the defender missed the 1-1 draw against Brighton.
But Irons boss David Moyes otherwise has a clean bill of health to choose from.
The away side meanwhile saw Trevoh Chalobah add to their growing injury list during the 2-1 win over Watford.
Tuchel said: "The most worried I am is about the injury on Trevoh Chalobah. We got a lot of hits today.
"The doctor was on the field, 20 times it felt like, to treat players. It's a big loss with Trevoh.
"We have already some injured key players so I am worried about that because the next game is Saturday at 12:30."
Chelsea will hand a late fitness test to Reece James after the England star missed the trip to Vicarage Road but Romelu Lukaku is in line to start.
Ben Chilwell, N'Golo Kante and Mateo Kovacic will all miss out.
West Ham v Chelsea: Match facts
West Ham have won three of their last six home Premier League games against Chelsea (D1 L2), as many as they had in their previous 14 such games against them in the competition (D3 L8).
Chelsea did the league double over West Ham last season. They last won three in a row against them in the Premier League between March 2010 and April 2011.
West Ham have lost two of their last four Premier League London derbies (W1 D1), as many as they had in their previous 10 such games (W4 D4). However, they won their last derby match in the competition against Spurs, last winning consecutive meetings with London clubs in January 2019 (a run of three).
Chelsea have won their last seven away league London derbies, an all-time record in the top four tiers of English football. The Blues have kept six clean sheets in this run, with their only goal conceded coming via Christian Benteke in April.
West Ham are winless in three Premier League games (D1 L2), last having a longer run without a win in their final four matches of 2020 (D3 L1).
Chelsea have made 50 changes to their starting XI in the Premier League this season, the most by a side after 14 matches of a season since Man Utd in 2009-10 (also 14 games); the only team to make 50 earlier into a season was Man Utd again, in 2001-02 (12th game).
With five goals and five assists, Michail Antonio has been involved in 10 goals in his last 10 Premier League London derby appearances. Antonio is the only West Ham player in Premier League history to register double figures for both goals (11) and assists (10) in London derby matches.
Chelsea manager Thomas Tuchel has won eight of his nine Premier League London derby matches (L1), with the Blues scoring 17 and conceding just twice in these games. In English top-flight history, the German has the best win rate in such games among managers to take charge of more than one (89%).
Against no side has Chelsea's Romelu Lukaku scored more Premier League goals than he has against West Ham (9). He could become the seventh player to net double figures against the Hammers in the Premier League, which would be the most opposing players to score 10+ against a side in the competition.
West Ham midfielder Tomas Soucek scored his 15th Premier League last time out against Brighton and Hove Albion, with only Michail Antonio scoring more for the Hammers (25) since Soucek's debut in February 2020. Only three Czech players have ever scored more goals in Premier League history: Patrik Berger (38), Milan Baros (28) and Tomas Rosicky (19).