The Premier League champions were without their all-conquering head coach for the last two games before the international break.
Guardiola was not on the touchline for City's 2-1 victory over Sheffield United nor their 5-1 hammering of Fulham after undergoing back surgery.
The Spaniard was recuperating in his home country for the past few weeks but remained in contact with his backroom staff throughout.
The 52-year-old is expected to be back this week to retake the reigns from assistant manager Juanma Lillo to give City an added boost.
Guardiola has a dominant record over West Ham boss David Moyes, having won 10 and lost just once in their 14 meetings as managers.
City are already comfortably top of the Premier League as the only side with a perfect record after four games, but the Irons are just two points adrift in fourth after a great start themselves.
West Ham vs Man City: talkSPORT coverage
This Premier League match will take place on Saturday, September 16.
Kick-off at the London Stadium will take place at 3pm.
Unfortunately, this fixture will not be televised on UK screens due to the 3pm blackout in English football.
However, talkSPORT will cover all the goals as they go in from West Ham against Man City as part of our GameDay Live coverage.
Join Adrian Durham, Trevor Sinclair and Ray Parlour from 2:30pm as they take you through all the action in east London, as well as Tottenham v Sheffield United and the rest of the EFL.
Manchester United's clash with Brighton will also be available on talkSPORT 2 while talkSPORT.com will be on hand for all the reaction.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
West Ham vs Man City: Team news
Mohammed Kudus could make his first start for the hosts having made his debut as a substitute in the 2-1 win over Luton Town.
And he could be joined by fellow new signing Konstantinos Mavropanos, who recovered from a back injury to star for Greece during the break.
Man City could hand Matheus Nunes his debut with talisman Kevin De Bruyne out injured for up to four months.
Jack Grealish also remains a doubt having had to pull out of England duty with a thigh issue, but John Stones could return here.
West Ham vs Man City: What has been said?
West Ham boss Moyes has spoken to talkSPORT about the possibility of Jesse Lingard rejoining the Hammers on a permanent deal.
Speaking on The Sports Breakfast show with Ally McCoist and Andy Townsend, Moyes said: "Jesse has trained with us for three weeks and he's improved greatly from when he first came in.
"He's in really good condition - much better condition than he was when he first came in.
"I have to say, when Jesse joined us two years ago I think he scored nine goals in 15 games and was probably the difference between us getting into Europe for the first time.
"I want to give him every opportunity to get himself back in condition and see how he does.
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"So there's no real update on it at the moment, just to say that he's back and getting much closer to the levels of fitness where you'd hope he would be."
West Ham vs Man City: Match facts
West Ham midfielder James Ward-Prowse has scored or assisted at least once in each of his last five games in the Premier League (2 goals, 4 assists), the second time he's done so in the top-flight after December 2021-January 2022 for Southampton. Ward-Prowse has never been directly involved in a goal in six successive Premier League matches.
Erling Haaland's opening four Premier League games for Manchester City this season have mirrored his record from his opening four games last season - a brace on MD1, no goals on MD2, one goal on MD3 and a hat-trick on MD4. The Norwegian scored a hat-trick on MD5 last season against Nottingham Forest.
David Moyes earned 40 points from 22 games against Manchester City in the Premier League while he was in charge of Everton (W12 D4 L6), while he has since picked up just two points from 13 games against them with Manchester United, Sunderland and current club West Ham (D2 L11).
Man City boss Pep Guardiola is unbeaten in all 14 of his Premier League games against West Ham, winning 12 and drawing two. Only Alex Ferguson faced an opponent more as a manager in the competition without ever losing (16 vs Charlton).
Only one of the 13 teams who were unbeaten at least four games into a Premier League campaign have won when hosting the competition's reigning champions (D7 L5), with Liverpool winning 3-1 against Manchester City in November 2019 in their 12th game of the 2019-20 season (W10 D1 going into it).
West Ham have lost nine of their last 10 Premier League matches against the competition's reigning champions (D1), conceding at least two goals in nine of those. They have beaten the reigning champions five times in total, with each of the last four instances coming in home games - December 2007 vs Manchester United, October 2014 vs Manchester City, October 2015 and December 2017 vs Chelsea.
Manchester City have lost just one of their last 11 games in the Premier League against teams starting the day inside the top four at least five matches into a season (W8 D2), with that defeat coming away to Manchester United in January of last season.
After drawing with Bournemouth on the opening day, West Ham have won each of their last three league matches, and could win four in a row for the first time since November 2021. With 10 points, this is the Hammers' joint-best start to a Premier League campaign after four games, along with 1999-2000, when they came ninth under Harry Redknapp.
Manchester City are unbeaten in their last eight Premier League away games against West Ham, since a 2-1 loss in October 2014. They've scored 24 goals in these eight visits, while conceding just six times in return.
West Ham are winless in their last 15 Premier League games against Manchester City (D3 L12), since a 2-1 away win in September 2015. Only against Manchester United (16 between 1993 and 2001) have the Hammers had a longer run without a win in the competition.