The Gunners dropped two points against Liverpool last Sunday in a thrilling 2-2 draw that allowed Manchester City to cut the gap at the top to six points.
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Mikel Arteta's men were 2-0 up and cruising but had to endure a second-half barrage from the hosts as they left Merseyside with a point and now travel to east London.
West Ham are in need of the points as well as they are locked in a desperate relegation battle.
David Moyes' men have won just three of their last 26 home league games against the Gunners and have only beaten Arsenal twice in the Premier League.
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West Ham vs Arsenal: Date and talkSPORT coverage
This Premier League clash is set to take place on Sunday, April 16.
Kick-off at the London Stadium is scheduled for 2pm.
The match will be broadcast on Sky Sports Main Event and Sky Sports Premier League, with coverage scheduled to start at 1pm on the latter channel.
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Sky Go customers will be able to stream the game through their laptop or mobile devices, while a NOW TV day-pass can be purchased for non-Sky customers for £11.99.
talkSPORT will have updates from east London throughout the afternoon and talkSPORT.com will have a live blog.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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West Ham vs Arsenal: Team news
The Irons managed to start Michail Antonio, Lucas Paqueta, Lukasz Fabianski and Tomas Soucek on the bench against Gent in midweek, suggesting they will come back into the team.
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However, Gianluca Scamacca is expected to miss out once more with a knee issue.
But barring any niggles picked up on Thursday, Moyes should have a strong squad to pick from.
Meanwhile, Arsenal have been boosted by the return of Eddie Nketiah.
Mohamed Elneny and Takehiro Tomiyasu are out for the season, while William Saliba has yet to participate in training due to an ongoing back problem.
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West Ham vs Arsenal: What has been said?
talkSPORT's Laura Woods doesn't believe Arsenal finishing second would be a failure.
Speaking on talkSPORT Breakfast, she said: "Of course I will be disappointed, massively disappointed, but they (Arsenal) were supposed to fail every minute, after the first few games, and at Christmas.
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"Come the New Year, Arsenal were supposed to fall away and they haven't. They have proved everyone wrong.
"I don't like these kind of binary arguments about if you win the league or if it is a failure.
"I think there is so much more you can celebrate in football, so for me, no.
"If you're asking me as an Arsenal fan, do I remember the 2022/23 season, I will say yes, it was amazing.
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"And yes, we missed out on the league, if Arsenal lost it for example, but I had some amazing memories from that season.
"As an individual, if you're asking a fan, if it is a failure, some will say no, but others may say yes."
West Ham vs Arsenal: Match facts
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West Ham United have won just two of their last 29 Premier League games against Arsenal (D5 L22), winning 2-0 away in August 2015 and 1-0 at home in January 2019.
Arsenal have only lost three of their 26 Premier League visits to West Ham (W14 D9) and have won nine of their last 14 away games against the Hammers (D4 L1).
Arsenal have won eight Premier League games against West Ham after conceding the first goal, including a 3-1 victory in the reverse fixture at the Emirates in December. It's both the most wins Arsenal have against an opponent when conceding first, and the most defeats West Ham have against a side when opening the scoring in the competition.
Arsenal have won all five of their away London derbies in the Premier League this season, by an aggregate score of 11-0. Only twice before have they won six consecutive league derbies on the road, doing so in February 1989 and March 2014.
West Ham have won two of their last three Premier League games (L1), as many as they had in their previous 14. They're looking to win back-to-back league games for the first time since October but lost 5-1 in their last home game against Newcastle.
Arsenal have won 11 Premier League away games this season, only winning more on the road in 2001-02 (14) and 2004-05 (12). The Gunners have the most wins (11), most points (35), most goals scored (30) and fewest goals conceded (11) of any team away from home in the Premier League this term.
Arsenal have scored 72 goals from an xG of 60.1 in the Premier League this season, with their difference of +11.9 bettered only by Manchester City (12.2). Meanwhile, West Ham have scored 27 goals from an xG of 38.4, with their difference of -11.4 the biggest negative difference this term.
Arsenal are the only team yet to lose a Premier League game when scoring the first goal this season, winning 18 and drawing three. However, they did let a two-goal lead slip in their 2-2 draw at Liverpool last time out.
Gabriel Martinelli has been involved in four goals in his four Premier League starts for Arsenal against West Ham (3 goals, 1 assist), netting his first ever goal in the competition in this fixture in December 2019. Against no side has the Brazilian been involved in more league goals for the Gunners.
Arsenal's Bukayo Saka has had 45 ball carries ending in either a shot (21) or a chance created (24) in the Premier League this season, more than any other player. On top of this, no player has been involved in more goals following a carry (6) than Saka this term (3 goals, 3 assists).