The Irons have enjoyed a perfect start to the group stages so far after recording back-to-back wins over Dinamo Zagreb and Rapid Vienna.
David Moyes' side also claimed a victory over Everton in the Premier League at the weekend and will be brimming with confidence ahead of the clash with the Belgian side.
West Ham may have half an eye on this weekend's clash with London rivals Tottenham but Moyes will want no mistakes against Genk.
West Ham v Genk: Date and time
The Europa League clash is due to take place on Thursday, October 20.
It will be played at the London Stadium in Stratford and kick-off will be at 8pm UK time.
West Ham v Genk: TV channel and live stream
The contest will be broadcast live on BT Sport 2 with their coverage starting at 7.30pm.
BT Sport subscribers can live stream this match via the app on their computer, mobile and tablet devices.
talkSPORT's Hugh Woozencroft will have live updates from this match on Kick-Off 'Around the Grounds'.
West Ham v Genk: Team news
David Moyes has revealed that Tomas Soucek will be available for the Europa League clash.
The midfielder was brought off after a clash of heads with Everton's Salomon Rondon at the weekend, but has been passed fit to be involved.
Nikola Vlasic will also be pushing for a start as the West Ham boss considers rotating his squad.
Ale Kral, Vladimir Coufal and Ryan Fredericks are also doubts after missing the clash with the Toffees.
For Genk, Daniel Munoz will miss out as he serves a suspension.
West Ham v Genk: What has been said?
West Ham boss David Moyes said: "I'm really enjoying it. We're a really happy club at the moment.
"Everyone's enjoying the league games, Europe and the Carabao Cup, so I have to say I'm really enjoying the European experience.
"I want the players to go far in it. It would be great if we could top the group, but trying to make sure that we go through would be the main aim at the moment."