The Dragons are fourth in Group D, only ahead of winless minnows Latvia, but their fate just about remains in their hands.
Rob Page's side have lost icon Gareth Bale along with Joe Allen, Chris Gunter and Jonny Williams to retirement since the World Cup.
And two defeats from their following four games look to have ended their Euro 2024 hopes before they beat Latvia 2-0 last month.
Another victory would see Wales join Croatia in second on 10 points, with crunch clashes against third-placed Armenia and table-toppers Turkey still to come.
These two teams drew 1-1 when they met in March, with Nathan Broadhead scoring a stoppage-time equaliser to rescue a point.
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Wales vs Croatia: How to follow
This Euro 2024 Group D qualifier will take place on Sunday, October 15.
The game will be played at the Cardiff City Stadium and will kick off at 7:45pm.
It will be broadcast live on Viaplay Sports 1 with coverage beginning at 7:35pm.
Fans can subscribe to Viaplay for £14.99 per month and can watch the game on their TV or website.
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talkSPORT will have updates throughout the evening.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
ou can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Wales vs Croatia: Team news
The hosts are without captain Aaron Ramsey due to injury so Tottenham defender Ben Davies will take the armband.
Both Dan James and Harry Wilson should return to the starting XI having been benched for the 4-0 friendly win over Gibraltar.
Robbie Savage's son Charlie impressed during that game, registering an assist on his international debut, and may retain his spot.
Croatia are missing Andrej Kramaric and Feyenoord winger Luka Ivanusec through injury.
Wales vs Croatia: What has been said?
Wales captain Davies: "Last time, we had two matches at the end where we had to win and we did it.
"People don't tend to remember how you get there - the most important thing is that you get there.
"It will be difficult. We know we're not in a situation we want to be in but we still have a chance.
"These are massive games coming up and we need to go into them ready to battle and win them all."