The teams are in Group H of this year's global event alongside Portugal and Ghana, who will go head-to-head in the other group encounter.
Diego Alonso's men have failed to win six of their last seven opening fixtures at football's biggest competition, and another slow start in Qatar could have serious ramifications for the South Americans.
On the other hand, South Korea claimed an impressive albeit insignificant victory over Germany in their last World Cup outing, which should give Paulo Bento's men reason to believe they can come out on top in this one.
Here, Sports Mole looks at how the squads of Uruguay and South Korea stack up against each other ahead of the contest.
URUGUAY
Most valuable player:
Federico Valverde (£86.2m)
Overall squad value:
£388m
Most capped player:
Diego Godin (159)
Leading goalscorer:
Luis Suarez (68)
Total caps:
1183
Total goals:
173
Oldest player:
Diego Godin (36)
Youngest player:
Facundo Pellistri (20)
Average age:
27.8
SQUAD IN FULL
Goalkeepers: Fernando Muslera (Galatasaray), Sergio Rochet (Nacional), Sebastian Sosa (Independiente)
Defenders: Diego Godin (Velez Sarsfield), Jose Gimenez (Atletico Madrid), Martin Caceres (LA Galaxy), Sebastian Coates (Sporting Lisbon), Matias Vina (Roma), Ronald Araujo (Barcelona), Guillermo Varela (Flamengo), Mathias Olivera (Napoli), Jose Luis Rodriguez (Nacional)
Midfielders: Matias Vecino (Lazio), Rodrigo Bentancur (Tottenham Hotspur), Federico Valverde (Real Madrid), Giorgian de Arrascaeta (Flamengo), Lucas Torreira (Galatasaray), Nicolas de la Cruz (River Plate), Manuel Ugarte (Sporting)
Forwards: Luis Suarez (Nacional), Edinson Cavani (Valencia), Maxi Gomez (Trabzonspor), Darwin Nunez (Liverpool), Facundo Torres (Orlando City), Facundo Pellistri (Manchester United), Agustin Canobbio (Athletico Paranaense)
SOUTH KOREA
Most valuable player:
Heung-min Son (£60.4m)
Overall squad value:
£142.4m
Most capped player:
Heung-min Son (104)
Leading goalscorer:
Heung-min Son (35)
Total caps:
922
Total goals:
113
Oldest player:
Kim Tae-hwan (33)
Youngest player:
Lee Kang-in (21)
Average age:
27.5
SQUAD IN FULL
Goalkeepers: Kim Seung-gyu (Al-Shabab), Jo Hyeon-woo (Ulsan Hyundai), Song Bum-keun (Jeonbuk Hyundai Motors)
Defenders: Kim Jin-su (Jeonbuk Hyundai Motors), Hong Chul (Daegu FC), Kim Moon-hwan (Jeonbuk Hyundai Motors), Kim Young-gwon (Ulsan Hyundai), Kwon Kyung-won (Gamba Osaka), Kim Tae-hwan (Ulsan Hyundai), Cho Yu-min (Daejon Hana Citizen), Kim Min-jae (Napoli), Yoon Jong-gyu (FC Seoul)
Midfielders: Jung Woo-young (Al-Sadd), Lee Jae-sung (Mainz), Hwang In-beom (Olympiacos), Na Sang-ho (FC Seoul), Paik Seung-ho (Jeonbuk Hyundai Motors), Kwon Chang-hoon (Gimcheon Sangmu), Paik Seung-ho (Jeonbuk Hyundai Motors), Son Jun-ho (Shandong Taishan), Jeong Woo-yeong (Freiburg), Lee Kang-in (Mallorca), Yang Hyun-jun (Gangwon FC)
Forwards: Son Heung-min (Tottenham), Hwang Ui-jo (Olympiacos), Cho Gue-sung (Jeonbuk Hyundai Motors), Hwang Hee-chan (Wolves)
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