United boss Ole Gunnar Solskjaer is under immense pressure following last weekend's hopeless defeat at home to Liverpool.
While Solskjaer has survived the sack, he'll need to start putting things right as soon as possible and stating with Saturday's trip to north London.
Spurs have had a mixed campaign as well and lost to West Ham last time out.
Both sides could do with a morale-boosting result and performance and there will be plenty on the line.
This fixture was littered with goals last season with United winning 3-1 in the capital and Spurs claiming an incredible 6-1 win at Old Trafford.
Tottenham v Man United: talkSPORT commentary
This Premier League clash will kick-off at 5:30pm on Saturday, October 30.
Hugh Woozencroft will be your host and commentary will come from Sam Matterface and former West Ham and England striker Dean Ashton.
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Tottenham v Man United: Team news
Tottenham have no major issues to contend with but Bryan Gil is a doubt with a hamstring problem.
Dele Alli will be hoping to be included in the squad.
Ryan Sessegnon remains out.
For United, Raphael Varane could return from his recent thigh injury.
However, Paul Pogba is suspended following his red card against Liverpool.
Anthony Martial remains a doubt while the likes of Jadon Sancho, Jesse Lingard and Donny van de Beek are pushing for starts.
Tottenham v Man United: Match facts
Tottenham have lost more Premier League games against Manchester United than they have versus any other side in the competition (36).
After a six-game winless run away to Tottenham in the Premier League (D3 L3), Manchester United have won two of their last three visits to Spurs in the competition (D1).
Just one of the last six Premier League matches between Tottenham and Manchester United have been won by the home side, with Manchester United winning 2-1 at Old Trafford in December 2019.
Manchester United have lost three of their last four Premier League matches (D1), as many as in their previous 37 league games (W23 D11). The Red Devils have not lost three Premier League games in a row since December 2015 under Louis van Gaal.
Manchester United's record 29-game away unbeaten run in the Premier League ended in their last match on the road against Leicester. They last lost consecutive away games in the competition in the two matches that preceded their unbeaten run - against Arsenal and Liverpool in January 2020.
Nuno Espírito Santo has lost four of his first nine Premier League matches as Spurs manager (W5) - the only manager to lose more than four of his first 10 Premier League games in charge of Tottenham was Christian Gross in 1997-98, who lost five.
Manchester United have conceded 10 Premier League goals this October, more than any other side. They have only conceded more than 10 in two calendar months, shipping 11 in October 1996 and December 2018. They have also conceded 4+ goals in their last two league games (2-4 vs Leicester, 0-5 vs Liverpool), last doing so in more consecutive league games in December 1961 (three in a row).
Tottenham's Son Heung-min had a hand in four goals in his two games against Manchester United last season (3 goals, 1assist), having failed to register a single goal involvement in his first eight appearances against the Red Devils.
Mason Greenwood has scored five goals in his last seven away Premier League appearances and nine overall on the road for Manchester United - at 20 years and 29 days on the day of this game, he could become the youngest player to score 10 away Premier League goals since Wayne Rooney (19y 21d) in November 2004, with Rooney scoring his 10th goal away at Newcastle for Manchester United.
After netting three goals in his first two Premier League appearances for Man Utd this season, Cristiano Ronaldo hasn't scored in any of his last four league matches, his worst run since November 2017 for Real Madrid (also four in a row). He hasn't gone five in a row without a goal since a run of nine for the Red Devils between November 2008 and January 2009.