Ange Postecoglou's side secured their spot in the fourth round of the FA Cup last time out courtesy of a 1-0 victory over Burnley at the Tottenham Hotspur Stadium.
Spurs beat Bournemouth 3-1 in their last league match, meanwhile, and they currently sit fifth in the table, just one point behind fourth-placed Arsenal.
Here, Sports Mole rounds up their latest injury and suspension news ahead of the clash with Man United, who are currently down in eighth position in the division.
James Maddison
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Maddison remains on the sidelines as he recovers from an ankle ligament injury, with the England international facing a battle to return to action before the end of the month.
Ivan Perisic
Status: Out
Type of injury: Knee
Possible return date: Unknown
Perisic underwent surgery on an ACL injury in September, and Postecoglou recently admitted that the 34-year-old, who is out of contract this summer, is unlikely to represent the club again.
Manor Solomon
Status: Out
Type of injury: Knee
Possible return date: Unknown
Solomon has been sidelined since October due to a knee injury which he picked up in training, and he will be missing for the North London club until at least the end of the month.
Alfie Whiteman
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Whiteman remains on the sidelines due to a severe ankle injury, with the goalkeeper unlikely to be available for selection until next season.
Cristian Romero
Status: Minor doubt
Type of injury: Hamstring
Possible return date: January 14 (vs. Man United)
Romero has recently been on the sidelines due to a hamstring injury, but the centre-back has returned to full training and is in contention to feature at Old Trafford.
Alejo Veliz
Status: Out
Type of injury: Knee
Possible return date: Unknown
Veliz suffered a knee injury against Bournemouth, and the forward has been ruled out "for a couple of months", according to Tottenham head coach Postecoglou.
Ben Davies
Status: Major doubt
Type of injury: Hamstring
Possible return date: January 14 (vs. Man United)
Davies is a major doubt for the game with Man United this weekend, having suffered a hamstring problem during the FA Cup clash with Burnley last time out.
Giovani Lo Celso
Status: Major doubt
Type of injury: Hamstring
Possible return date: January 14 (vs. Man United)
Lo Celso will require a late fitness test to determine his availability for this match, with the midfielder also battling to overcome a hamstring issue which he suffered against Burnley.
Son Heung-min
Status: Out
Possible return date: Unknown
Spurs are currently without their captain Son due to his involvement in the Asian Cup.
Pape Sarr
Status: Out
Possible return date: Unknown
Spurs are currently without Sarr due to his involvement in the Africa Cup of Nations.
Yves Bissouma
Status: Out
Possible return date: Unknown
Spurs are currently without Bissouma due to his involvement in the Africa Cup of Nations.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Tottenham have no players suspended for this match.