The North Londoners have not been in action since they earned a 2-2 draw with Manchester United on January 14, twice coming from behind against the Red Devils at Old Trafford.
A weekend off felt necessary for a side that has availability issues, but that is expected to ease for the visit of the defending champions to the Tottenham Hotspur Stadium.
Here, Sports Mole rounds up their latest injury and suspension news ahead of the clash with City, who have also been without a game since the weekend of January 13 and 14.
James Maddison
Status: Major doubt
Type of injury: Ankle
Possible return date: January 26 (vs. Manchester City)
While James Maddison has been sidelined since November with an ankle ligament injury, the playmaker is preparing to step up his recovery with a return to full training. However, if he is declared fit for this game, it will only be for a place on the substitutes' bench.
Manor Solomon
Status: Major doubt
Type of injury: Knee
Possible return date: January 26 (vs. Manchester City)
Manor Solomon falls under the same bracket as Maddison, the winger having been out in the long term with a knee injury but back in training ahead of this fixture. Again, a spot among the replacements could be handed to the Israel international.
Alfie Whiteman
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Alfie Whiteman remains on the sidelines due to a severe ankle injury, with the goalkeeper unlikely to be available for selection until next season.
Alejo Veliz
Status: Out
Type of injury: Knee
Possible return date: Unknown
Alejo Veliz suffered a knee injury against Bournemouth, and the forward has been ruled out "for a couple of months", according to Tottenham head coach Postecoglou.
Ben Davies
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Ben Davies suffered a hamstring problem during the FA Cup clash with Burnley last time out, and he is now set to be on the sidelines until the back end of February.
Giovani Lo Celso
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Giovani Lo Celso sustained a hamstring issue earlier this month and the current expectation is that the playmaker will be sidelined until some point in February.
Son Heung-min
Status: Out
Possible return date: Unknown
Spurs are currently without their captain Son Heung-min due to his involvement in the Asian Cup with South Korea.
Pape Sarr
Status: Out
Possible return date: Unknown
Spurs are currently without Pape Sarr due to his involvement with Senegal in the Africa Cup of Nations.
Yves Bissouma
Status: Out
Possible return date: Unknown
Spurs are currently without Yves Bissouma due to his involvement with Mali at the Africa Cup of Nations.
Ryan Sessegnon
Status: Minor doubt
Type of injury: Hamstring
Possible return date: January 26 (vs. Manchester City)
Having suffered a minor hamstring injury, Ryan Sessegnon missed the Man United game. However, Postecoglou has indicated that the left-sided player should return to the fold for this contest.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Tottenham have no players suspended for this match.