Ange Postecoglou has witnessed his team put together a strong run in the Premier League of late, accumulating 12 points from a possible 15 over the Christmas and New Year period.
While the North Londoners sit in fifth place in the table, they have a strong desire to lift silverware in this competition, albeit having to start their campaign without a wide array of senior players.
Here, Sports Mole rounds up their latest injury and suspension news ahead of welcoming Burnley to the Tottenham Hotspur Stadium.
Micky van de Ven
Status: Out
Type of injury: Hamstring
Possible return date: January 14 (vs. Manchester United)
Micky van de Ven has been sidelined with a hamstring injury since the beginning of November, but the centre-back has a chance of returning to action against Manchester United in the middle of the month.
James Maddison
Status: Out
Type of injury: Ankle
Possible return date: Unknown
James Maddison remains on the sidelines as he recovers from an ankle ligament injury, and the attacker is unlikely to be available for selection until the end of January.
Ivan Perisic
Status: Out
Type of injury: Knee
Possible return date: Unknown
Ivan Perisic underwent surgery on an ACL injury in September, and the Croatian is now facing a major battle to be available for selection before the end of the campaign.
Ryan Sessegnon
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Ryan Sessegnon is yet to feature this season due to a hamstring problem, and there is currently no indication when he could be available for selection.
Manor Solomon
Status: Out
Type of injury: Knee
Possible return date: Unknown
Manor Solomon has been sidelined since October due to a knee injury which he picked up in training, and the attacker is not expected to be available until the end of January at the earliest.
Alfie Whiteman
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Alfie Whiteman is facing a lengthy spell on the sidelines due to a severe ankle injury, with the goalkeeper in a battle to return before the end of the campaign.
Cristian Romero
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Cristian Romero is facing a battle to return before the end of January due to a hamstring problem, and it is likely to be the start of February before he is seen in a Spurs shirt again.
Pape Matar Sarr
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Pape Matar Sarr was forced off during the first half against Bournemouth at the weekend with a hamstring injury. While the Senegal international had been due to link up with his country for the Africa Cup of Nations, that is now very much in doubt.
Alejo Veliz
Status: Minor doubt
Type of injury: Knock
Possible return date: December 5 (vs. Burnley)
Alejo Veliz sustained a knock towards the end of the game with the Cherries soon after his introduction as a substitute. Even if the Argentine is passed fit, he will only be selected among the replacements at best.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Yves Bissouma
Status: Out
Possible return date: Unknown
Yves Bissouma is serving a four-game suspension due to the red card that he was handed against Nottingham Forest, meaning that he will not be back until January 14 at the earliest, but the midfielder is set to represent Mali at the Africa Cup of Nations, so his return date is unknown at this stage.