When the fourth official's board goes up, you enter a stage of the match where the nerves are more frayed than ever and one mistake or one moment of magic can prove decisive with little or no time left to respond.
It is a time when heroes and villains are made, lasting memories are forged and the absolute peak time for drama in a sport which provides so many twists and turns.
While some injury-time goals are enough to earn three points, others are even more significant, winning knockout ties, cup finals and even league titles in the most dramatic fashion.
Incredibly, May 8 marks two of the most famous examples of an injury-time winner in football history, with goalkeeper Jimmy Glass memorably scoring to keep Carlisle United up on this date in 1999, and Lucas Moura unforgettably sending Tottenham Hotspur into the Champions League final at Ajax's expense exactly 20 years later.
The anniversaries gives us the perfect chance to look back on some of the other incredible last-gasp finales and where Glass and Lucas rank among football's most dramatic winners.
The rules for inclusion are as follows:
Only goals scored in stoppage time at the end of matches, i.e. beyond the 90-minute or 120-minute marks, count.
Only goals that were directly responsible for winning a match, tie or title count, which means no David Beckham vs. Greece or Steven Gerrard vs. West Ham United, for example.
So, without further ado, here is Sports Mole list of the 20 greatest injury-time winners in the history of football.
20. Dennis Bergkamp - Netherlands (vs. Argentina)
Kicking off this countdown in style, Dennis Bergkamp produced arguably the best goal in this countdown and on one of the biggest stages too - the 1998 World Cup quarter-final.
Netherlands and Argentina were locked at 1-1 in Marseille when the clock ticked over 90, with Claudio Lopez having earlier cancelled out Patrick Kluivert's opener.
A moment of magic was needed, so step forward Bergkamp. Frank de Boer sent a pinpoint 60-yard pass towards the Arsenal maestro, who produced a delicious first touch to control it, played it through the legs of Roberto Ayala with his second and then volleyed past Carlos Roa with his third - one of the best goals in World Cup history.
Not only did it send Netherlands through to the semi-finals of the World Cup, where they lost to Brazil incidentally, but it also saw Bergkamp become the all-time record goalscorer for his country.
19. Felipe Santana - Borussia Dortmund (vs. Malaga)
Last-gasp winners are all the better when they come after an unlikely comeback, and Dortmund produced one of the most unlikely in Champions League history against Malaga in 2013.
The two sides had played out a goalless draw in the first leg of the quarter-final in Spain, and Dortmund's hopes of progressing further looked bleak when Eliseu made it 2-1 to Malaga with only seven minutes remaining.
The away-goals rule meant that Dortmund needed two goals to make it into the semi-finals, which remained the case as the clock ticked into injury time.
Just as all hope seemed to have faded, Marco Reus pulled one of the goals back in the 91st minute, before Felipe Santana sent Jurgen Klopp and co into delirium with another just one minute after that.
In truth the goal should never have stood - Santana was just one of the Dortmund players offside - but the German outfit did not care as they went on to reach the final, where they lost to Bayern Munich.
18. Lionel Messi - Barcelona (vs. Real Madrid)
Of all the many, many goals Lionel Messi has scored throughout his glittering career, few would have brought him quite as much satisfaction as this one.
The defending champions trailed Real Madrid by three points having played a game more than their fiercest rivals when they visited the Bernabeu, and they knew that defeat would all but end their hopes of retaining the title.
Even a draw would have left things firmly in Madrid's hands, and James Rodriguez appeared to have earned that for the hosts with an 85th-minute equaliser after Sergio Ramos had been sent off.
Messi had earlier scored his 499th Barcelona goal with a fine solo effort, and he brought the significant 500 milestone up in the most dramatic fashion with a first-time finish into the bottom corner in the 92nd minute.
The goal sent Barcelona back to the top of the table with five games left courtesy of their head-to-head record, although Madrid made use of their game in hand to go on and pip their Clasico rivals to the title.
17. Dejan Lovren - Liverpool (vs. Borussia Dortmund)
Dortmund pulled off their own remarkable European comeback against Malaga in 2012-13, but three years later - and with Klopp now in the opposite dugout - they were on the wrong end of one at the hands of Liverpool here.
A 1-1 first-leg draw in Germany had given Liverpool the slight advantage heading back to Anfield, but within 10 minutes of the second leg starting they appeared to be heading out courtesy of quickfire goals from Henrikh Mkhitaryan and Pierre-Emerick Aubameyang.
Divock Origi pulled one back for the hosts shortly after half time, only for Marco Reus to restore Dortmund's two-goal lead to leave Liverpool needing three goals in the final half an hour.
The Reds are no strangers to epic comebacks, though, and goals from Philippe Coutinho (66') and Mamadou Sakho (77') pulled them level on the night and left them needing only one more to progress to the Europa League semi-finals.
It took until the 91st minute for that goal to finally come, and the unlikely source made it all the more dramatic as Dejan Lovren nodded home to send Anfield wild.
Liverpool went on to make it all the way to the final, where they were beaten by Sevilla.
16. Steve Bruce - Manchester United (vs. Sheffield Wednesday)
A goal which ranks among the most dramatic and most important in Premier League history; without Steve Bruce's 96th-minute winner against Sheffield Wednesday we may never have seen Manchester United go on to dominate the first two decades of the competition.
The Red Devils had gone 26 years without being crowned champions of England but were in the mix during the inaugural Premier League campaign, battling it out with Aston Villa at the top of the table.
The visiting Wednesday looked set to inflict a damaging defeat on United at Old Trafford when they led 1-0 with only five minutes remaining, but Bruce rediscovered his uncanny eye for goal at the opportune moment, ending a six-month drought in incredible fashion.
First the centre-back equalised in the 86th minute, and then six minutes into injury time he met Gary Pallister's cross with a bullet header that sent Sir Alex Ferguson and assistant Brian Kidd hopping onto the pitch in euphoria.
'Fergie Time' was born, United went on to win their first Premier League title and the foundations had been set for a dynasty which lasted 20 years.
15. Kelvin - Porto (vs. Benfica)
Ninety minutes into the penultimate game of the season and Portugal's two most successful teams, who are once again vying for the title, are locked at 1-1.
Porto had won eight of the previous 10 titles, but Benfica seemed to be on the verge of toppling their greatest foes with a two-point lead heading into their trip to the Estadio Do Dragao.
A draw would have left them only needing to match Porto's result on the final day of the season, whereas victory would have handed them the title in Porto's own backyard.
For the hosts, the only way to wrestle control of the title into their own hands was to win. Up stepped 19-year-old Kelvin, who had spent the majority of the season in the second tier with the reserves, with a stunning strike from an acute angle in the 91st minute to add a dramatic twist in a nip-and-tuck title race.
The win moved Porto one point clear of Benfica and they went on to win the title yet again the following week, while Kelvin never scored another league goal for the club.
14. David Gray - Hibernian (vs. Rangers)
Hibernian had not won the Scottish Cup for 114 years heading into the 2016 final against Rangers, while they only had a trio of Scottish League Cups to their name since last being crowned top-flight champions in 1951-52.
Rangers had already seen their fair share of drama on their way past Old Firm rivals Celtic in the semi-final, but they learned early that the final would not be any more straightforward as Hibs took the lead after only three minutes.
The favourites, who had lifted the trophy a whopping 30 times since Hibs last got their hands on it, hit back to lead 2-1, but Anthony Stokes doubled his personal tally with 10 minutes remaining to send the game heading towards extra time.
That was until Alan Stubbs's side won a corner in the second minute of injury time which captain David Gray met with a header that inked his name into Hibernian history - one of only 15 goals he scored in his entire senior career.
13. Ben Watson - Wigan Athletic (vs. Manchester City)
Three years earlier in the English FA Cup final there was an even bigger David vs. Goliath contest as Wigan Athletic came up against free-spending Manchester City at Wembley.
Man City had won the Premier League the previous season and were bidding for a second FA Cup in three years, whereas Wigan were on course for relegation from the top flight and had never won a major trophy in their entire history - the biggest previously had been League One or the Football League Trophy.
Yet the magic of the cup can never be counted out, and the Latics had already fared much better than many had expected when they reached injury time with the scores still goalless.
The match seemed destined for extra time, but in scenes remarkably similar to what would happen between Hibs and Rangers a few years later, a late Wigan corner led to Ben Watson's glancing header to seal one of the greatest FA Cup final upsets of all time.