Both teams will enter the match off the back of impressive league victories at the weekend, with Man United beating Newcastle United 4-1 and Young Boys thumping Zurich 4-0, and here Sports Mole rounds up the team news for the two sides ahead of their Group F contest.
YOUNG BOYS vs. MANCHESTER UNITED
YOUNG BOYS
Out: Fabian Lustenberger (Achilles), Jean-Pierre Nsame (Achilles), Joel Monteiro (knee), Esteban Petignat (muscle)
Doubtful: Nico Maier (unknown)
Sports Mole's predicted XI: Von Ballmoos; Hefti, Camara, Zesiger, Garcia; Fassnacht, Sierro, Aebischer, Ngamaleu; Elia, Siebatcheu
MANCHESTER UNITED
Out: Marcus Rashford (shoulder), Alex Telles (ankle)
Doubtful: Edinson Cavani (knock), Scott McTominay (groin), Dean Henderson (fitness), Phil Jones (fitness)
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Fred, Pogba; Greenwood, Fernandes, Sancho; Ronaldo